HitPredict

Interactor 1: CSN1 (P45432)
COP9 signalosome complex subunit 1 (CSN complex subunit 1) (Constitutive photomorphogenesis protein 11) (Protein FUSCA 6)
Gene: CSN1

Interactor 2: CSN4 (Q8L5U0)
COP9 signalosome complex subunit 4 (AtS4) (Signalosome subunit 4) (Constitutive photomorphogenesis protein 8) (Protein FUSCA 4)
Gene: CSN4

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	19175768, 10521526, 12615944, 11854419
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PCI~PCI, PCI~RPN7
Common GO terms	GO:0000338 - protein deneddylation GO:0008180 - COP9 signalosome GO:0009585 - red, far-red light phototransduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 441 At			1 397
+	Mm
		102342 G3UXW9_MOUSE (28-440): 4.8e-105: 323: 45.64		CSN4_MOUSE (10-390): 8.18e-133: 388: 49.48
+	Hs
		122017 PSMD6_HUMAN (32-428): 2.95e-109: 329: 19.35		PSD12_HUMAN (1-393): 8.19e-130: 382: 17.28
+	Hs
		1024211 CSN1_HUMAN (28-440): 1.81e-100: 310: 45.00		CSN4_HUMAN (10-390): 9.73e-133: 388: 49.74
+	At
		1226050 CSN2_ARATH (63-425): 8.77e-74: 239: 12.83		CSN4_ARATH (1-397): 8.92e-144: 416: 100.00
+	Hs
		121629 PSD11_HUMAN (67-429): 1.25e-80: 257: 14.56		PSD12_HUMAN (1-393): 8.19e-130: 382: 17.28
+	Dm
		1277030 CSN2_DROME (61-427): 2.6e-81: 259: 15.34		CSN4_DROME (11-389): 2.37e-129: 379: 47.64
+	Dm
		1180709 PSD11_DROME (71-430): 2.51e-80: 256: 14.68		CSN4_DROME (11-389): 2.37e-129: 379: 47.64
+	Mm
		291856 CSN2_MOUSE (62-427): 1.2e-75: 244: 14.85		CSN4_MOUSE (10-390): 8.18e-133: 388: 49.48
+	Hs
		897302 CSN2_HUMAN (62-427): 1.2e-75: 244: 14.85		CSN4_HUMAN (10-390): 9.73e-133: 388: 49.74
+	An
		1124336 CSN1_EMENI (6-436): 1.48e-98: 305: 35.62		CSN4_EMENI (3-390): 4.08e-108: 325: 39.70
+	Dm
		1358525 PSMD6_DROME (31-428): 1.38e-101: 309: 17.54		Q9V3Z4_DROME (16-392): 1.44e-103: 317: 16.15
+	Hs
		121977 EIF3E_HUMAN (41-440): 7.71e-75: 242: 11.87		PSD12_HUMAN (1-393): 8.19e-130: 382: 17.28
+	Dm
		1180715 PSD11_DROME (71-430): 2.51e-80: 256: 14.68		Q9V3Z4_DROME (16-392): 1.44e-103: 317: 16.15
+	Sc
		1015374 RPN6_YEAST (66-429): 1.84e-85: 270: 14.44		RPN5_YEAST (1-393): 2.21e-98: 302: 17.33
+	An
		1124316 CSN2_EMENI (66-418): 3.18e-75: 245: 15.30		CSN4_EMENI (3-390): 4.08e-108: 325: 39.70
+	Ce
		1325699 CSN1_CAEEL (13-440): 4.45e-80: 260: 24.69		CSN4_CAEEL (22-391): 1.34e-101: 308: 34.04
+	Ce
		136318 CSN2_CAEEL (64-421): 4.05e-77: 250: 13.41		CSN4_CAEEL (22-391): 1.34e-101: 308: 34.04
+	Sc
		985894 RPN7_YEAST (54-421): 9.49e-77: 247: 19.33		RPN5_YEAST (1-393): 2.21e-98: 302: 17.33
+	Sp
		143482 CSN2_SCHPO (82-421): 5.05e-63: 211: 13.35		CSN4_SCHPO (71-380): 2.58e-79: 250: 23.25