HitPredict

Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	16141199, 10523642, 10629060
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030424 - axon GO:0043066 - negative regulation of apoptotic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 1336
+	Hs
		864879 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Hs
		800962 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Mm
		1143154 MK10_MOUSE (1-427): 5.84e-164: 470: 89.46		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Mm
		1322366 MK09_MOUSE (1-427): 1.29e-160: 460: 81.50		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Mm
		1265205 MK08_MOUSE (1-381): 7.75e-152: 437: 99.48		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Mm
		926440 MK01_MOUSE (20-359): 2.95e-84: 263: 42.98		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		229640 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Mm
		1123147 MK08_MOUSE (1-381): 7.75e-152: 437: 99.48		JIP4_MOUSE (6-1336): 0: 681: 54.61
+	Mm
		814047 MK14_MOUSE (4-365): 9.55e-131: 382: 46.03		JIP4_MOUSE (6-1336): 0: 681: 54.61
+	Hs
		229677 MK14_HUMAN (4-365): 2.33e-130: 381: 46.03		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		229628 MK01_HUMAN (20-359): 2.94e-84: 263: 42.98		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Ce
		712388 JNK1_CAEEL (1-366): 1.19e-135: 398: 68.21		JIP_CAEEL (21-482): 2.09e-29: 129: 26.85
+	Hs
		625530 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		MY18A_HUMAN (189-793): 1.74e-25: 117: 9.00
+	Hs
		625177 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		625176 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		551610 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		1082568 MK14_HUMAN (4-365): 2.33e-130: 381: 46.03		FKB15_HUMAN (1-294): 8.91e-12: 72.2: 11.07
+	Rn
		600445 MK03_RAT (20-359): 1.42e-83: 262: 41.55		ROCK1_RAT (2-545): 9.22e-23: 108: 10.70
+	Rn
		926486 MK01_RAT (20-359): 2.95e-84: 263: 42.98		ROCK2_RAT (2-515): 3.57e-21: 103: 11.81