HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	22974441
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 481
+	Hs
		802892 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		548746 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		581044 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		956520 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Hs
		802639 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		235053 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235054 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151733 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		151734 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Mm
		724603 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Mm
		1141171 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOK3_MOUSE (1-458): 4.81e-120: 360: 30.90
+	Hs
		235042 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151706 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		802675 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		562631 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Mm
		724599 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		581086 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Mm
		946348 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		IRS2_MOUSE (6-371): 1.55e-70: 245: 15.10
+	Rn
		88884 GRB2_RAT (135-297): 2.78e-25: 102: 15.67		D4A244_RAT (154-464): 1.16e-58: 203: 22.68
+	Mm
		1141149 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73