HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: ATN1 (P54259)
Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)
Gene: ATN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27684187, 35044719
Identification Methods	affinity chromatography technology, unspecified method, phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003713 - transcription coactivator activity GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1190
+	Hs
		125277 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ATN1_HUMAN (1-1190): 1.67e-152: 490: 100.00
+	Hs
		125556 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		Q86V38_HUMAN (1-1190): 4.18e-151: 486: 98.83
+	Hs
		869511 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ATN1_HUMAN (1-1190): 1.67e-152: 490: 100.00
+	Hs
		869535 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		ATN1_HUMAN (1-1190): 1.67e-152: 490: 100.00
+	Hs
		869516 MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32		ATN1_HUMAN (1-1190): 1.67e-152: 490: 100.00
+	Hs
		869548 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		ATN1_HUMAN (1-1190): 1.67e-152: 490: 100.00
+	Hs
		1200930 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		Q86V38_HUMAN (1-1190): 4.18e-151: 486: 98.83
+	Hs
		554367 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		MUC1_HUMAN (4-696): 5.81e-38: 157: 13.23
+	Hs
		125061 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24D_HUMAN (162-388): 1.97e-10: 67.5: 24.32
+	Hs
		125274 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24C_HUMAN (69-393): 4.74e-09: 63.1: 16.87
+	Hs
		808779 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2C_HUMAN (73-701): 1.56e-19: 97.8: 17.13
+	Hs
		808716 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		SRCAP_HUMAN (327-1016): 7.44e-14: 79.1: 12.90
+	Hs
		808612 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		NCOA6_HUMAN (260-799): 2.05e-10: 67.5: 8.99
+	Dm
		1374363 SUDX_DROME (16-504): 4.46e-109: 347: 15.74		Q9VUH6_DROME (303-776): 5.04e-10: 66.2: 13.47
+	Hs
		1170084 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SRCAP_HUMAN (327-1016): 7.44e-14: 79.1: 12.90
+	Hs
		1057793 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		NCOA6_HUMAN (260-799): 2.05e-10: 67.5: 8.99
+	Hs
		203253 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SYNJ1_HUMAN (515-960): 3.78e-09: 63.6: 15.66
+	Sc
		758550 TOM1_YEAST (261-504): 2.18e-46: 176: 11.34		SEC31_YEAST (20-356): 1.4e-10: 68.1: 13.02
+	Dm
		1115153 YAP1_DROME (52-268): 1.16e-44: 163: 29.25		Q9VUH6_DROME (303-776): 5.04e-10: 66.2: 13.47
+	Hs
		867138 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		SC24C_HUMAN (69-393): 4.74e-09: 63.1: 16.87