Protein: PKN1
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)

Gene: PKN1
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q16512

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0001783 - B cell apoptotic process
GO:0002634 - regulation of germinal center formation
GO:0002637 - regulation of immunoglobulin production
GO:0003014 - renal system process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962090

RHOA
Transforming protein RhoA

5

20

Small-scale

0.929

High

978035

RHOB
Rho-related GTP-binding protein RhoB

3

20

Small-scale

0.834

High

1157505

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

15

High-throughput

0.783

High

241803

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.754

High

923353

MK12
Mitogen-activated protein kinase 12

1

20

Small-scale

0.747

High

1157490

LRC61
Leucine-rich repeat-containing protein 61

2

0

High-throughput

0.742

High

252248

CCNT2
Cyclin-T2

1

8

Small-scale

0.740

High

186550

TRI18
E3 ubiquitin-protein ligase Midline-1

1

15

High-throughput

0.740

High

1103753

PLD1
Phospholipase D1

1

4

Small-scale

0.724

High

193581

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

Small-scale

0.713

High

1157443

PKN1
Serine/threonine-protein kinase N1

1

17

Small-scale

0.710

High

719330

MPIP3
M-phase inducer phosphatase 3

1

0

Small-scale

0.708

High

1157499

HOME3
Homer protein homolog 3

4

5

High-throughput

0.703

High

1157444

PKN2
Serine/threonine-protein kinase N2

1

18

High-throughput

0.691

High

1157493

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

11

High-throughput

0.691

High

1157510

PLAL2
Zinc finger protein PLAGL2

1

1

High-throughput

0.691

High

848782

MAGAA
Melanoma-associated antigen 10

4

2

High-throughput

0.691

High

1090665

TRAF2
TNF receptor-associated factor 2

3

13

Small-scale

0.679

High

1145953

K1H1
Keratin, type I cuticular Ha1

3

13

High-throughput

0.675

High

1033357

CDR2
Cerebellar degeneration-related protein 2

4

0

Small-scale

0.670

High

858663

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

Small-scale

0.665

High

912505

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

17

Small-scale

0.665

High

1055656

GABP1
GA-binding protein subunit beta-1

1

8

High-throughput

0.665

High

1157461

CCNJL
Cyclin-J-like protein

1

10

High-throughput

0.665

High

1157502

ZN581
Zinc finger protein 581

1

5

High-throughput

0.665

High

1157507

IKZF3
Zinc finger protein Aiolos

1

1

High-throughput

0.665

High

1157509

ZN232
Zinc finger protein 232

1

3

High-throughput

0.665

High

1093828

TRAF1
TNF receptor-associated factor 1

3

7

Small-scale

0.658

High

1157503

ZN282
Zinc finger protein 282

1

1

High-throughput

0.656

High

1157471

KBTB8
Kelch repeat and BTB domain-containing protein 8

3

5

Small-scale

0.656

High

571991

TRI27
Zinc finger protein RFP

3

8

Small-scale

0.653

High

988395

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

474702

VIME
Vimentin

2

13

Small-scale

0.641

High

1042626

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.638

High

1157489

AKAP9
A-kinase anchor protein 9

2

9

Small-scale

0.633

High

1157475

ZFP90
Zinc finger protein 90 homolog

1

0

High-throughput

0.630

High

451168

NFL
Neurofilament light polypeptide

2

12

Small-scale

0.618

High

411999

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.618

High

436676

KPCB
Protein kinase C beta type

1

16

Small-scale

0.618

High

461523

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468414

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

555696

ACTN1
Alpha-actinin-1

1

3

Small-scale

0.618

High

728263

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.618

High

830814

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

1107758

SQSTM
Sequestosome-1

1

7

High-throughput

0.618

High

1153366

MK11
Mitogen-activated protein kinase 11

1

20

Small-scale

0.618

High

1157445

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

1157454

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1157470

ABCF1
ATP-binding cassette sub-family F member 1

1

2

High-throughput

0.618

High

1157495

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.618

High

1157500

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

4

Small-scale

0.618

High

1063281

GOGA2
Golgin subfamily A member 2

3

8

High-throughput

0.616

High

300366

KRT34
Keratin, type I cuticular Ha4

2

12

High-throughput

0.606

High

300573

KRT36
Keratin, type I cuticular Ha6

2

12

High-throughput

0.606

High

300656

KRT37
Keratin, type I cuticular Ha7

2

13

High-throughput

0.606

High

475584

K1C19
Keratin, type I cytoskeletal 19

2

11

High-throughput

0.606

High

476324

K1C16
Keratin, type I cytoskeletal 16

2

11

High-throughput

0.606

High

700894

PSB4
Proteasome subunit beta type-4

2

3

High-throughput

0.606

High

928185

HAP1
Huntingtin-associated protein 1

2

6

High-throughput

0.606

High

1007928

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.606

High

1157448

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

10

High-throughput

0.606

High

1157449

INT11
Integrator complex subunit 11

2

2

High-throughput

0.606

High

1157460

CEP57
Centrosomal protein of 57 kDa

2

2

High-throughput

0.606

High

1157469

PNMA1
Paraneoplastic antigen Ma1

2

4

High-throughput

0.606

High

1157481

KRT35
Keratin, type I cuticular Ha5

2

13

High-throughput

0.606

High

1157483

HAUS1
HAUS augmin-like complex subunit 1

2

1

High-throughput

0.606

High

1157488

SPAG5
Sperm-associated antigen 5

2

9

High-throughput

0.606

High

1157492

TSG10
Testis-specific gene 10 protein

2

9

High-throughput

0.606

High

1157497

PICK1
PRKCA-binding protein

2

7

High-throughput

0.606

High

1157504

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.606

High

61051

FUCM
Fucose mutarotase

2

0

High-throughput

0.602

High

50902

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.580

High

131438

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.580

High

269212

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1093622

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

1157462

DAA19
Dynein axonemal assembly factor 19

2

0

High-throughput

0.580

High

1157463

UBR2
E3 ubiquitin-protein ligase UBR2

2

0

High-throughput

0.580

High

1157472

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.580

High

1157473

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.580

High

1157487

RAB3I
Rab-3A-interacting protein

2

0

High-throughput

0.580

High

1157494

GO45
Golgin-45

2

0

High-throughput

0.580

High

1157496

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.580

High

1157498

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.580

High

1157506

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.580

High

1153708

NDF2
Neurogenic differentiation factor 2

1

1

Small-scale

0.573

High

618036

K1C15
Keratin, type I cytoskeletal 15

1

11

High-throughput

0.573

High

1157464

CE57L
Centrosomal protein CEP57L1

1

2

High-throughput

0.573

High

1154517

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.558

High

65052

GG6L9
Golgin subfamily A member 6-like protein 9

2

8

High-throughput

0.553

High

1157452

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.553

High

1157467

USBP1
Harmonin-binding protein USHBP1

2

7

High-throughput

0.553

High

1157513

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

272666

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

7

High-throughput

0.536

High

1157474

RBCC1
RB1-inducible coiled-coil protein 1

1

13

High-throughput

0.536

High

1157480

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.536

High

630284

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

8

Small-scale

0.528

High

551617

NFH
Neurofilament heavy polypeptide

1

17

Small-scale

0.527

High

422175

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.515

High

688014

EF1G
Elongation factor 1-gamma

1

7

High-throughput

0.515

High

1126692

BECN1
Beclin-1

1

1

High-throughput

0.515

High

1157451

Q6PJH3
A kinase

1

2

High-throughput

0.515

High

1157465

MIER1
Mesoderm induction early response protein 1

1

2

High-throughput

0.515

High

1157466

KCD17
BTB/POZ domain-containing protein KCTD17

1

9

High-throughput

0.515

High

1157501

STMN3
Stathmin-3

1

1

High-throughput

0.515

High

1157508

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.515

High

1157476

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.513

High

1157491

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.513

High

388074

MBP
Myelin basic protein

1

3

Small-scale

0.501

High

529876

TAU
Microtubule-associated protein tau

1

13

Small-scale

0.501

High

715605

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

Small-scale

0.501

High

840064

CASP3
Caspase-3

1

4

Small-scale

0.501

High

1157456

H32
Histone H3.2

1

8

Small-scale

0.501

High

1157512

HDAC5
Histone deacetylase 5

1

7

Small-scale

0.501

High

246621

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.500

High

1157486

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

483489

INHBB
Inhibin beta B chain

1

1

High-throughput

0.489

High

706135

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

1157447

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1157453

CERS6
Ceramide synthase 6

1

3

High-throughput

0.489

High

649787

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.486

High

457468

TBB5
Tubulin beta chain

1

9

Small-scale

0.479

High

695570

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

764788

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

768296

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

948842

CD81
CD81 antigen

1

3

High-throughput

0.479

High

1106552

SMAD4
Mothers against decapentaplegic homolog 4

1

9

High-throughput

0.479

High

1142549

PDK1
[Pyruvate dehydrogenase

1

4

Small-scale

0.479

High

1146682

PCBP1
Poly(rC)-binding protein 1

1

4

Small-scale

0.479

High

1157457

TBA1A
Tubulin alpha-1A chain

1

12

Small-scale

0.479

High

1157458

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1157482

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1157511

PA2G4
Proliferation-associated protein 2G4

1

1

Small-scale

0.479

High

1157477

THAP3
THAP domain-containing protein 3

1

1

High-throughput

0.470

High

224897

BUD23
18S rRNA

1

0

High-throughput

0.460

High

127094

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

1157450

ABLM2
Actin-binding LIM protein 2

1

4

High-throughput

0.445

High

1157484

CC136
Coiled-coil domain-containing protein 136

1

11

High-throughput

0.439

High

1157468

ARL10
ADP-ribosylation factor-like protein 10

1

5

High-throughput

0.437

High

1157455

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

3

0

High-throughput

0.347

High

1157514

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

70220

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

286658

STX11
Syntaxin-11

2

0

High-throughput

0.316

High

582336

ARSA
Arylsulfatase A

2

0

High-throughput

0.316

High

1157459

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1157479

DYDC1
DPY30 domain-containing protein 1

2

0

High-throughput

0.316

High

1157485

CC138
Coiled-coil domain-containing protein 138

2

0

High-throughput

0.316

High

1157478

CB015
Uncharacterized protein C2orf15

1

0

High-throughput

0.268

Low

1157446

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025