HitPredict

Interactor 1: SMC3 (P47037)
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)
Gene: SMC3

Interactor 2: SCC2 (Q04002)
Sister chromatid cohesion protein 2
Gene: SCC2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	27307603, 37739959, 14614819, 29932904, 23499533
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Nipped-B_C~SMC_N
Common GO terms	GO:0005634 - nucleus GO:0007064 - mitotic sister chromatid cohesion GO:0034087 - establishment of mitotic sister chromatid cohesion GO:1990414 - replication-born double-strand break repair via sister chromatid exchange
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1230 Sc			1 1493
+	Sc
		700798 SMC1_YEAST (2-1215): 4.84e-68: 253: 16.53		SCC2_YEAST (1-1493): 0: 1921: 100.00
+	Sc
		758755 SMC2_YEAST (1-1210): 3.6e-64: 240: 18.41		SCC2_YEAST (1-1493): 0: 1921: 100.00
+	Mm
		1154102 SMC3_MOUSE (1-1228): 2.61e-91: 322: 30.28		NIPBL_MOUSE (358-1387): 0: 1069: 18.85
+	Hs
		1154087 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		NIPBL_HUMAN (358-1387): 0: 1063: 18.67
+	Mm
		1154101 SMC1A_MOUSE (2-1222): 6.7e-73: 268: 16.41		NIPBL_MOUSE (358-1387): 0: 1069: 18.85
+	Hs
		1057289 SMC1A_HUMAN (2-1222): 6.7e-73: 268: 16.41		NIPBL_HUMAN (358-1387): 0: 1063: 18.67
+	Sp
		293285 SMC1_SCHPO (2-1215): 9.46e-66: 246: 16.94		MIS4_SCHPO (277-1385): 0: 956: 22.13