Protein: SKI8
Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]

Gene: SKI8, SKIC8
Organism: Homo sapiens
Interactions: 180
UniProt ID: Q9GZS3

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243857

CTR9
RNA polymerase-associated protein CTR9 homolog

7

17

Small-scale

0.966

High

1149464

SKI2
Superkiller complex protein 2

3

20

Small-scale

0.855

High

1244373

SKI3
Superkiller complex protein 3

3

18

Small-scale

0.855

High

1155740

EZH2
Histone-lysine N-methyltransferase EZH2

2

18

High-throughput

0.793

High

610879

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.789

High

821561

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.789

High

876163

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.789

High

899222

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.789

High

1007266

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.789

High

1240693

CDC73
Parafibromin

9

1

Small-scale

0.751

High

1330562

PAF1
RNA polymerase II-associated factor 1 homolog

7

5

Small-scale

0.745

High

908227

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

4

High-throughput

0.737

High

1102372

GRB10
Growth factor receptor-bound protein 10

2

3

High-throughput

0.737

High

1357911

LEO1
RNA polymerase-associated protein LEO1

6

6

Small-scale

0.732

High

882149

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.691

High

899572

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.691

High

1041594

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.691

High

1148041

SF3B3
Splicing factor 3B subunit 3

1

16

High-throughput

0.691

High

1363693

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.691

High

1407560

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.691

High

1428695

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

18

High-throughput

0.691

High

182183

PFD6
Prefoldin subunit 6

3

6

High-throughput

0.667

High

963368

PFD3
Prefoldin subunit 3

3

6

High-throughput

0.667

High

1404661

PFD5
Prefoldin subunit 5

3

7

High-throughput

0.667

High

1428703

PFD2
Prefoldin subunit 2

3

4

High-throughput

0.667

High

822854

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.665

High

1098373

ERCC8
DNA excision repair protein ERCC-8

1

18

High-throughput

0.665

High

261871

PFD1
Prefoldin subunit 1

2

5

High-throughput

0.628

High

286066

SF3B1
Splicing factor 3B subunit 1

2

7

High-throughput

0.628

High

1428696

PFD4
Prefoldin subunit 4

2

5

High-throughput

0.628

High

843962

HD
Huntingtin

2

1

High-throughput

0.621

High

157828

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.618

High

302950

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.618

High

315993

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

854929

RECQ1
ATP-dependent DNA helicase Q1

1

19

High-throughput

0.618

High

907574

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

9

High-throughput

0.618

High

971053

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.618

High

998786

H31
Histone H3.1

1

8

Small-scale

0.618

High

1137514

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.618

High

1138616

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.618

High

1157919

DDB1
DNA damage-binding protein 1

1

16

Small-scale

0.618

High

1255450

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1415860

DDA1
DET1- and DDB1-associated protein 1

1

3

Small-scale

0.618

High

1428694

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1115047

CUL4A
Cullin-4A

2

20

Small-scale

0.611

High

1312654

MSRB3
Methionine-R-sulfoxide reductase B3

2

1

High-throughput

0.606

High

1274049

PHF5A
PHD finger-like domain-containing protein 5A

2

0

High-throughput

0.602

High

242858

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.601

High

3498

A0A0S2Z5Q7
Alsin Rho guanine nucleotide exchange factor ALS2

1

6

High-throughput

0.594

High

884395

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

Small-scale

0.575

High

990988

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.575

High

1244718

TTC33
Tetratricopeptide repeat protein 33

2

9

High-throughput

0.574

High

396902

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

130607

SPT5H
Transcription elongation factor SPT5

1

7

High-throughput

0.536

High

136133

PLK4
Serine/threonine-protein kinase PLK4

1

9

High-throughput

0.536

High

471919

RU2B
U2 small nuclear ribonucleoprotein B''

1

13

High-throughput

0.536

High

478203

SNRPA
U1 small nuclear ribonucleoprotein A

1

9

High-throughput

0.536

High

480304

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

542209

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

564346

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

574465

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

5

High-throughput

0.536

High

625612

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.536

High

909180

NEK4
Serine/threonine-protein kinase Nek4

1

8

High-throughput

0.536

High

974041

RUXF
Small nuclear ribonucleoprotein F

1

15

High-throughput

0.536

High

974661

SMD2
Small nuclear ribonucleoprotein Sm D2

1

4

High-throughput

0.536

High

977582

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

High-throughput

0.536

High

981689

RAN
GTP-binding nuclear protein Ran

1

6

High-throughput

0.536

High

994364

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

High-throughput

0.536

High

1006945

KC1G2
Casein kinase I isoform gamma-2

1

8

High-throughput

0.536

High

1065419

SSRP1
FACT complex subunit SSRP1

1

19

High-throughput

0.536

High

1105408

SF3B2
Splicing factor 3B subunit 2

1

2

High-throughput

0.536

High

1107188

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

Small-scale

0.536

High

1115412

CUL4B
Cullin-4B

1

20

Small-scale

0.536

High

1148653

SF3A2
Splicing factor 3A subunit 2

1

5

High-throughput

0.536

High

1149188

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.536

High

1370362

CSN5
COP9 signalosome complex subunit 5

1

7

High-throughput

0.536

High

1390380

CCD97
Coiled-coil domain-containing protein 97

1

1

High-throughput

0.536

High

1395246

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

3

High-throughput

0.536

High

1416248

SF3B5
Splicing factor 3B subunit 5

1

2

High-throughput

0.536

High

1428706

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.536

High

1428709

SF3B6
Splicing factor 3B subunit 6

1

14

High-throughput

0.536

High

1226732

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.530

High

654678

TCEA1
Transcription elongation factor A protein 1

1

2

Small-scale

0.516

High

831393

CCNF
Cyclin-F

1

8

High-throughput

0.515

High

231760

PEX1
Peroxisomal ATPase PEX1

1

7

High-throughput

0.515

High

333186

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.515

High

386208

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

High-throughput

0.515

High

423114

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

479612

DOPO
Dopamine beta-hydroxylase

1

1

High-throughput

0.515

High

570589

GFAP
Glial fibrillary acidic protein

1

6

High-throughput

0.515

High

686648

ELAV4
ELAV-like protein 4

1

3

High-throughput

0.515

High

703251

HXD10
Homeobox protein Hox-D10

1

7

High-throughput

0.515

High

791700

SYUA
Alpha-synuclein

1

4

High-throughput

0.515

High

890051

PSN1
Presenilin-1

1

4

High-throughput

0.515

High

901551

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.515

High

927534

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

1096216

TADBP
TAR DNA-binding protein 43

1

12

High-throughput

0.515

High

1123811

DCTN1
Dynactin subunit 1

1

17

High-throughput

0.515

High

1156362

SYUB
Beta-synuclein

1

4

High-throughput

0.515

High

1199372

GLE1
mRNA export factor GLE1

1

16

High-throughput

0.515

High

1235105

TTBK2
Tau-tubulin kinase 2

1

10

High-throughput

0.515

High

1275967

SETX
Probable helicase senataxin

1

5

High-throughput

0.515

High

1279736

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1404895

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.515

High

1419462

PANK2
Pantothenate kinase 2, mitochondrial

1

1

High-throughput

0.515

High

1428710

RNF11
RING finger protein 11

1

2

High-throughput

0.515

High

1364040

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

Small-scale

0.513

High

691410

1433T
14-3-3 protein theta

1

17

High-throughput

0.501

High

361354

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

713132

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.493

High

1159359

FRDA
Frataxin, mitochondrial

1

0

High-throughput

0.493

High

1277823

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.493

High

1347937

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.493

High

1428701

ATX10
Ataxin-10

1

0

High-throughput

0.493

High

1406771

BARD1
BRCA1-associated RING domain protein 1

1

9

High-throughput

0.481

High

1428704

ERRFI
ERBB receptor feedback inhibitor 1

1

3

Small-scale

0.481

High

132285

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

173328

XPO1
Exportin-1

1

13

High-throughput

0.479

High

260427

BRD4
Bromodomain-containing protein 4

1

15

High-throughput

0.479

High

294297

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

406622

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

596341

H12
Histone H1.2

1

10

Small-scale

0.479

High

636145

CD11B
Cyclin-dependent kinase 11B

1

8

High-throughput

0.479

High

637723

FLNA
Filamin-A

1

12

High-throughput

0.479

High

664812

CCND1
G1/S-specific cyclin-D1

1

8

Small-scale

0.479

High

700729

PSA5
Proteasome subunit alpha type-5

1

4

Small-scale

0.479

High

711189

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.479

High

766832

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

769121

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

786837

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

7

High-throughput

0.479

High

827483

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.479

High

879448

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.479

High

881602

CDK8
Cyclin-dependent kinase 8

1

14

High-throughput

0.479

High

965225

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.479

High

990706

1433Z
14-3-3 protein zeta/delta

1

17

High-throughput

0.479

High

1037361

H11
Histone H1.1

1

10

Small-scale

0.479

High

1045746

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1053739

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

4

Small-scale

0.479

High

1100356

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.479

High

1114244

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1115996

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.479

High

1124411

ELOA1
Elongin-A

1

5

Small-scale

0.479

High

1158527

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.479

High

1161660

IF16
Gamma-interferon-inducible protein 16

1

9

High-throughput

0.479

High

1194367

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

1229675

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1235516

IFIX
Pyrin and HIN domain-containing protein 1

1

9

High-throughput

0.479

High

1260625

ASXL2
Putative Polycomb group protein ASXL2

1

16

High-throughput

0.479

High

1329856

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1353460

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

1

High-throughput

0.479

High

1361055

ASB15
Ankyrin repeat and SOCS box protein 15

1

6

High-throughput

0.479

High

1364584

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1367218

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1428698

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

1428699

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1428702

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1428705

FZR1
Fizzy-related protein homolog

1

15

High-throughput

0.479

High

1428707

CD11A
Cyclin-dependent kinase 11A

1

8

High-throughput

0.479

High

1428708

NUDC
Nuclear migration protein nudC

1

15

High-throughput

0.479

High

1428711

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

High-throughput

0.479

High

1428712

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.479

High

705548

GRN
Progranulin

1

1

High-throughput

0.470

High

890776

PSN2
Presenilin-2

1

4

High-throughput

0.470

High

1337543

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

1147271

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1330925

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1339699

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1428697

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

106619

APRIO
Alternative prion protein

1

3

Small-scale

0.439

High

1290711

ZCH18
Zinc finger CCCH domain-containing protein 18

1

19

High-throughput

0.437

High

1421195

ASXL3
Putative Polycomb group protein ASXL3

1

12

High-throughput

0.437

High

1125

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1010973

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

622268

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

1238326

Q6NUL7
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low

1360743

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1391501

BSCL2
Seipin

1

0

High-throughput

0.268

Low

1428700

Q9P1N4
PRO1359

1

0

High-throughput

0.268

Low

1327184

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1214193

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025