HitPredict

Interactor 1: ZO1 (P39447)
Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: Tjp1

Interactor 2: VINC (Q64727)
Vinculin (Metavinculin)
Gene: Vcl

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.526

Property	Details
Experiments	24413171
Identification Methods	anti bait coimmunoprecipitation, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005912 - adherens junction GO:0032991 - protein-containing complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1745 Mm			1 1066
+	Hs
		613342 ZO1_HUMAN (1-1745): 0: 1015: 90.79		VINC_HUMAN (1-1066): 0: 811: 90.56
+	Hs
		1058965 ZO1_HUMAN (1-1745): 0: 1015: 90.79		MRCKB_HUMAN (433-1051): 2.05e-104: 362: 12.32
+	Hs
		764317 ZO1_HUMAN (1-1745): 0: 1015: 90.79		CTNA1_HUMAN (5-907): 2.67e-75: 269: 15.82
+	Mm
		684456 ZO1_MOUSE (1-1745): 0: 1017: 100.00		CTNA1_MOUSE (5-907): 3.09e-74: 266: 15.82
+	Hs
		299733 MPDZ_HUMAN (90-503): 4.48e-22: 106: 17.06		VINC_HUMAN (1-1066): 0: 811: 90.56
+	Hs
		168765 CSKP_HUMAN (217-804): 8.93e-89: 313: 14.10		CTNL1_HUMAN (659-1052): 1.56e-53: 202: 14.85
+	Hs
		764321 DLG1_HUMAN (1-112): 3.28e-25: 116: 31.58		CTNA1_HUMAN (5-907): 2.67e-75: 269: 15.82
+	Hs
		764319 PTN13_HUMAN (20-492): 3.7e-23: 110: 17.42		CTNA1_HUMAN (5-907): 2.67e-75: 269: 15.82
+	Hs
		764397 DLG5_HUMAN (262-508): 1.03e-17: 92.2: 15.47		CTNA1_HUMAN (5-907): 2.67e-75: 269: 15.82
+	Hs
		764459 ZO2_HUMAN (399-625): 7.16e-10: 66.5: 18.30		CTNA1_HUMAN (5-907): 2.67e-75: 269: 15.82