HitPredict

Interactor 1: CAZA2 (P47755)
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)
Gene: CAPZA2

Interactor 2: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding GO:0051016 - barbed-end actin filament capping
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 350
+	Hs
		857109 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		TWF1_HUMAN (1-350): 5.66e-171: 481: 100.00
+	Hs
		813067 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Hs
		857151 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Hs
		813214 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		COF2_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		618015 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Sc
		659122 CAPZA_YEAST (8-282): 5.61e-91: 272: 30.94		TWF1_YEAST (1-334): 4.1e-86: 264: 24.65