HitPredict - High confidence protein-protein interactions

Interactor 1: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Interactor 2: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21713032
Identification Methods	molecular sieving
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	TNF~TNF
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005102 - signaling receptor binding GO:0005123 - death receptor binding GO:0005125 - cytokine activity GO:0005164 - tumor necrosis factor receptor binding and 36 others more... GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0005901 - caveola GO:0006915 - apoptotic process GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006925 - inflammatory cell apoptotic process GO:0007165 - signal transduction GO:0007267 - cell-cell signaling GO:0008284 - positive regulation of cell population proliferation GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0009897 - external side of plasma membrane GO:0016525 - negative regulation of angiogenesis GO:0030644 - intracellular chloride ion homeostasis GO:0032496 - response to lipopolysaccharide GO:0043065 - positive regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043202 - lysosomal lumen GO:0043525 - positive regulation of neuron apoptotic process GO:0045742 - positive regulation of epidermal growth factor receptor signaling pathway GO:0046666 - retinal cell programmed cell death GO:0048388 - endosomal lumen acidification GO:0048471 - perinuclear region of cytoplasm GO:0060205 - cytoplasmic vesicle lumen GO:0070062 - extracellular exosome GO:0070231 - T cell apoptotic process GO:0070266 - necroptotic process GO:0070848 - response to growth factor GO:0071346 - cellular response to type II interferon GO:0097190 - apoptotic signaling pathway GO:0097191 - extrinsic apoptotic signaling pathway GO:0097527 - necroptotic signaling pathway GO:1903514 - release of sequestered calcium ion into cytosol by endoplasmic reticulum GO:1905782 - positive regulation of phosphatidylserine exposure on apoptotic cell surface GO:2000353 - positive regulation of endothelial cell apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	281
Hs

1	281

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024