Protein: LIS1
Nuclear distribution protein PAC1 (Lissencephaly-1 homolog) (LIS-1) (nudF homolog)

Gene: LIS1, PAC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P39946

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0005634 - nucleus
GO:0005635 - nuclear envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

779758

DYHC
Dynein heavy chain, cytoplasmic

7

7

Small-scale

0.961

High

815641

LIS1
Nuclear distribution protein PAC1

5

16

Small-scale

0.919

High

815667

NDE1
Nuclear distribution protein nudE homolog 1

5

0

Small-scale

0.682

High

815651

UBC9
SUMO-conjugating enzyme UBC9

1

10

Small-scale

0.621

High

815657

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

9

High-throughput

0.621

High

815668

ULS1
ATP-dependent helicase ULS1

1

15

Small-scale

0.621

High

815673

CAF1A
Chromatin assembly factor 1 subunit A

1

9

High-throughput

0.621

High

806026

KEL1
Kelch repeat-containing protein 1

2

10

High-throughput

0.595

High

798140

ARPC1
Actin-related protein 2/3 complex subunit 1

1

19

High-throughput

0.595

High

548207

BIK1
Nuclear fusion protein BIK1

2

9

Small-scale

0.584

High

815647

STU2
Protein STU2

2

6

Small-scale

0.584

High

626751

HSP60
Heat shock protein 60, mitochondrial

1

20

High-throughput

0.578

High

725966

SWC3
SWR1-complex protein 3

2

0

High-throughput

0.570

High

797878

CENPU
Inner kinetochore subunit AME1

2

0

High-throughput

0.570

High

815649

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.570

High

815658

UBC7
Ubiquitin-conjugating enzyme E2 7

1

20

High-throughput

0.528

High

815662

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.518

High

448730

SNF1
Carbon catabolite-derepressing protein kinase

1

5

High-throughput

0.501

High

367759

ENO1
Enolase 1

1

4

High-throughput

0.500

High

439347

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.500

High

590633

HSP26
Heat shock protein 26

1

1

High-throughput

0.500

High

486191

TBA1
Tubulin alpha-1 chain

1

14

High-throughput

0.481

High

509566

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

17

Small-scale

0.481

High

646042

KIN3
Serine/threonine-protein kinase KIN3

1

19

High-throughput

0.481

High

664295

SSD1
Protein SSD1

1

3

High-throughput

0.481

High

665825

KPC1
Protein kinase C-like 1

1

16

High-throughput

0.481

High

750669

PRS6A
26S proteasome regulatory subunit 6A

1

11

High-throughput

0.481

High

755240

NUF2
Kinetochore protein NUF2

1

7

High-throughput

0.481

High

802510

SYSM
Serine--tRNA ligase, mitochondrial

1

4

High-throughput

0.481

High

805817

WSS1
DNA-dependent metalloprotease WSS1

1

1

Small-scale

0.481

High

809184

END3
Actin cytoskeleton-regulatory complex protein END3

1

8

High-throughput

0.481

High

815644

PFD2
Prefoldin subunit 2

1

7

High-throughput

0.481

High

815650

HMS2
Probable transcription factor HMS2

1

6

High-throughput

0.481

High

815652

PFD6
Prefoldin subunit 6

1

7

High-throughput

0.481

High

815654

NST1
Stress response protein NST1

1

20

High-throughput

0.481

High

815661

VPS60
Vacuolar protein-sorting-associated protein 60

1

8

High-throughput

0.481

High

815664

VPS20
Vacuolar protein sorting-associated protein 20

1

8

High-throughput

0.481

High

815669

SRL2
Protein SRL2

1

1

High-throughput

0.481

High

815670

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

Small-scale

0.481

High

815672

SMT3
Ubiquitin-like protein SMT3

1

2

Small-scale

0.481

High

815671

RPN5
26S proteasome regulatory subunit RPN5

1

5

Small-scale

0.479

High

626508

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.460

High

776318

MRP8
Uncharacterized protein MRP8

1

0

High-throughput

0.460

High

782573

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.460

High

796311

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

815643

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.460

High

815645

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

815655

NIS1
Protein NIS1

1

0

Small-scale

0.460

High

815656

DAD4
DASH complex subunit DAD4

1

0

High-throughput

0.460

High

815660

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

815663

ECM11
Protein ECM11

1

0

High-throughput

0.460

High

561252

CG13
G1/S-specific cyclin CLN3

1

6

High-throughput

0.457

High

359479

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

4

High-throughput

0.457

High

815646

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

804893

LAM4
Membrane-anchored lipid-binding protein LAM4

1

1

High-throughput

0.439

High

815659

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

14

High-throughput

0.437

High

815642

YEC3
Uncharacterized protein YEL023C

1

0

High-throughput

0.269

Low

815653

NNF2
Protein NNF2

1

0

High-throughput

0.265

Low

790324

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

815648

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.251

Low

815665

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.251

Low

815666

FMP27
Protein FMP27, mitochondrial

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025