HitPredict

Interactor 1: PRS4 (P48601)
26S proteasome regulatory subunit 4 (P26s4)
Gene: Rpt2

Interactor 2: Q9VJJ0 (Q9VJJ0)
Proteasome subunit beta
Gene: Prosbeta4

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Dm			1 201
+	Sc
		604819 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PSB4_YEAST (1-197): 3.02e-79: 236: 39.90
+	Hs
		832083 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSB2_HUMAN (1-195): 2.08e-77: 232: 51.28
+	At
		188708 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSB2A_ARATH (1-190): 8.82e-77: 230: 42.63
+	Sc
		675428 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PSB5_YEAST (2-200): 1.32e-68: 212: 16.58
+	At
		189246 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSB2B_ARATH (1-190): 1.2e-75: 227: 42.11
+	Dm
		820480 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		Q7K148_DROME (2-199): 7.21e-68: 210: 22.73
+	At
		286458 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA4A_ARATH (3-199): 5.83e-70: 214: 17.41
+	Dm
		771287 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		PSA2_DROME (4-201): 2.16e-66: 205: 15.50
+	At
		188699 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA2A_ARATH (3-201): 1.77e-69: 213: 20.30
+	At
		188714 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSB5A_ARATH (2-199): 4.68e-69: 213: 19.70
+	Dm
		820525 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		Q9VUJ1_DROME (4-198): 6.07e-65: 203: 22.56
+	Hs
		656694 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSB5_HUMAN (2-199): 1.21e-67: 209: 19.70
+	Hs
		637667 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA2_HUMAN (4-201): 1.9e-67: 208: 16.00
+	Hs
		906905 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSB7_HUMAN (3-198): 2.78e-66: 206: 21.94
+	Sc
		625948 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PSB2_YEAST (3-183): 4.6e-60: 190: 24.31
+	Hs
		156269 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA7_HUMAN (3-201): 6.13e-65: 202: 16.67
+	Hs
		638104 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA4_HUMAN (3-200): 4.59e-65: 202: 17.56
+	At
		189237 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA7B_ARATH (4-200): 1.63e-65: 203: 15.35
+	At
		188703 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSB7A_ARATH (3-194): 6.86e-65: 202: 22.40
+	Hs
		656441 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSB4_HUMAN (3-198): 8.57e-55: 176: 21.61