Protein: I27RA
Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)

Gene: I27RA, IL27RA
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q6UWB1

Gene Ontology (top 5):
GO:0002827 - positive regulation of T-helper 1 type immune response
GO:0002829 - negative regulation of type 2 immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
GO:0006955 - immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582386

B4GT1
Beta-1,4-galactosyltransferase 1

2

1

High-throughput

0.628

High

1187199

CC50B
Cell cycle control protein 50B

2

4

High-throughput

0.628

High

1248394

ULBP3
UL16-binding protein 3

2

10

High-throughput

0.628

High

1245862

BRID5
BRICHOS domain-containing protein 5

3

1

High-throughput

0.607

High

1236188

MFSD5
Molybdate-anion transporter

2

1

High-throughput

0.606

High

834672

TNFL9
Tumor necrosis factor ligand superfamily member 9

2

0

High-throughput

0.602

High

1248404

SCN3B
Sodium channel regulatory subunit beta-3

2

7

High-throughput

0.601

High

945190

CLD2
Claudin-2

2

0

High-throughput

0.580

High

1248390

S41A2
Solute carrier family 41 member 2

2

0

High-throughput

0.580

High

212068

B4GT5
Beta-1,4-galactosyltransferase 5

2

1

High-throughput

0.574

High

295748

AP1G2
AP-1 complex subunit gamma-like 2

2

6

High-throughput

0.574

High

698784

CALX
Calnexin

2

7

High-throughput

0.574

High

1215440

DEP1A
DEP domain-containing protein 1A

2

1

High-throughput

0.574

High

1247486

POTEE
POTE ankyrin domain family member E

2

6

High-throughput

0.574

High

1248396

TMX4
Thioredoxin-related transmembrane protein 4

2

7

High-throughput

0.574

High

1248397

TMX1
Thioredoxin-related transmembrane protein 1

2

9

High-throughput

0.574

High

1248399

DJC18
DnaJ homolog subfamily C member 18

2

6

High-throughput

0.574

High

1248410

FND3A
Fibronectin type-III domain-containing protein 3A

2

18

High-throughput

0.574

High

1248411

RHBD3
Rhomboid domain-containing protein 3

2

5

High-throughput

0.574

High

1248392

DERL3
Derlin-3

2

1

High-throughput

0.553

High

164366

NRP1
Neuropilin-1

1

6

High-throughput

0.536

High

175382

PLXB2
Plexin-B2

1

8

High-throughput

0.536

High

520890

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.536

High

541555

FGFR1
Fibroblast growth factor receptor 1

1

13

High-throughput

0.536

High

984166

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.536

High

1009151

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

10

High-throughput

0.536

High

1160914

PRSS8
Prostasin

1

9

High-throughput

0.536

High

1177224

MICA
MHC class I polypeptide-related sequence A

1

8

High-throughput

0.536

High

1248400

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

13

High-throughput

0.536

High

1248402

CC50A
Cell cycle control protein 50A

1

4

High-throughput

0.536

High

1248405

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

5

High-throughput

0.536

High

1248408

MINP1
Multiple inositol polyphosphate phosphatase 1

1

1

High-throughput

0.536

High

1248409

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.536

High

1248382

LRP11
Low-density lipoprotein receptor-related protein 11

1

0

High-throughput

0.513

High

1248386

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.513

High

1248387

GLMN
Glomulin

1

0

High-throughput

0.513

High

1248393

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.513

High

1248407

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.513

High

838121

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

7

Small-scale

0.512

High

62134

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

9

High-throughput

0.489

High

1191845

TBB8
Tubulin beta-8 chain

1

6

High-throughput

0.489

High

1248389

ZDH12
Palmitoyltransferase ZDHHC12

1

7

High-throughput

0.489

High

1248391

LENG8
Leukocyte receptor cluster member 8

1

6

High-throughput

0.489

High

1248395

LMA2L
VIP36-like protein

1

2

High-throughput

0.489

High

1248398

ZDHC6
Palmitoyltransferase ZDHHC6

1

4

High-throughput

0.489

High

1248406

KDIS
Kinase D-interacting substrate of 220 kDa

1

8

High-throughput

0.489

High

658721

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.479

High

1124169

IL27B
Interleukin-27 subunit beta

1

19

Small-scale

0.479

High

1248385

IL27A
Interleukin-27 subunit alpha

1

0

Small-scale

0.458

High

380077

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

4

High-throughput

0.445

High

409424

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.445

High

170819

CLGN
Calmegin

1

7

High-throughput

0.407

High

469109

SRPRA
Signal recognition particle receptor subunit alpha

2

0

High-throughput

0.328

High

1248383

PLD6
Mitochondrial cardiolipin hydrolase

2

0

High-throughput

0.328

High

1205419

DB121
Beta-defensin 121

2

0

High-throughput

0.316

High

1248384

GLT15
Polypeptide N-acetylgalactosaminyltransferase 15

2

0

High-throughput

0.316

High

1248388

YIPF6
Protein YIPF6

2

0

High-throughput

0.316

High

360274

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.279

Low

548040

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

963573

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.279

Low

1084046

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

0

High-throughput

0.279

Low

1211158

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.279

Low

1228349

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.279

Low

1248401

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

1248403

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025