HitPredict

Interactor 1: ECHA (P40939)
Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
Gene: HADHA

Interactor 2: ECHA (P40939)
Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
Gene: HADHA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 31839598
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 3HCDH~3HCDH, 3HCDH~3HCDH_N, 3HCDH~ECH_1, 3HCDH_N~3HCDH_N, 3HCDH_N~ECH_1, ECH_1~ECH_1
Common GO terms GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
and 8 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 763
Hs

1 763
+ Mm
+ Rn
+ Mm
+ Hs
+ Zm
+ Mm
+ Hs
+ Ce
+ Mt
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs

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Last updated: 11Aug2025