Protein: PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)

Gene: PDE2A
Organism: Homo sapiens
Interactions: 111
UniProt ID: O00408

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0003170 - heart valve development
GO:0003281 - ventricular septum development
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126973

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

2

6

Small-scale

0.802

High

127067

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

127011

ITSN1
Intersectin-1

1

2

High-throughput

0.541

High

118641

AIP
AH receptor-interacting protein

1

5

Small-scale

0.529

High

126974

SDCB1
Syntenin-1

1

4

High-throughput

0.479

High

126976

APAF
Apoptotic protease-activating factor 1

1

5

High-throughput

0.479

High

126978

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.479

High

126980

MRP5
ATP-binding cassette sub-family C member 5

1

1

High-throughput

0.479

High

126982

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

1

1

High-throughput

0.479

High

126989

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.479

High

126996

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

126997

MRP1
Multidrug resistance-associated protein 1

1

1

High-throughput

0.479

High

126999

CAV2
Caveolin-2

1

1

High-throughput

0.479

High

127002

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

127005

EPS8
Epidermal growth factor receptor kinase substrate 8

1

2

High-throughput

0.479

High

127007

TMED1
Transmembrane emp24 domain-containing protein 1

1

1

High-throughput

0.479

High

127012

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

127025

MON2
Protein MON2 homolog

1

1

High-throughput

0.479

High

127026

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

127033

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

High-throughput

0.479

High

127039

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

5

High-throughput

0.479

High

127042

TTC1
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.479

High

127046

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

High-throughput

0.479

High

127057

PLS3
Phospholipid scramblase 3

1

1

High-throughput

0.479

High

127064

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.479

High

127066

Z3H7B
Zinc finger CCCH domain-containing protein 7B

1

1

High-throughput

0.479

High

127068

S12A6
Solute carrier family 12 member 6

1

1

High-throughput

0.479

High

127072

S12A4
Solute carrier family 12 member 4

1

1

High-throughput

0.479

High

127073

BAIP2
BAR/IMD domain-containing adapter protein 2

1

3

High-throughput

0.479

High

127075

TMED5
Transmembrane emp24 domain-containing protein 5

1

1

High-throughput

0.479

High

61157

PDES1
Plasmanylethanolamine desaturase 1

1

0

High-throughput

0.458

High

126975

STX16
Syntaxin-16

1

0

High-throughput

0.458

High

126977

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

126979

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.458

High

126981

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.458

High

126983

ATP9B
Probable phospholipid-transporting ATPase IIB

1

0

High-throughput

0.458

High

126984

STX10
Syntaxin-10

1

0

High-throughput

0.458

High

126985

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.458

High

126987

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

126988

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.458

High

126991

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

126992

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.458

High

126994

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.458

High

126995

PEX2
Peroxisome biogenesis factor 2

1

0

High-throughput

0.458

High

126998

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

127000

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.458

High

127001

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.458

High

127003

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.458

High

127004

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.458

High

127006

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

127009

DAZP2
DAZ-associated protein 2

1

0

High-throughput

0.458

High

127010

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

127013

ANO6
Anoctamin-6

1

0

High-throughput

0.458

High

127014

PPM1L
Protein phosphatase 1L

1

0

High-throughput

0.458

High

127017

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.458

High

127018

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.458

High

127019

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

0

High-throughput

0.458

High

127022

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

127024

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

127027

RELL1
RELT-like protein 1

1

0

High-throughput

0.458

High

127028

ORML3
ORM1-like protein 3

1

0

High-throughput

0.458

High

127029

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.458

High

127031

RDH13
Retinol dehydrogenase 13

1

0

High-throughput

0.458

High

127032

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.458

High

127034

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.458

High

127035

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

127036

MARC2
Mitochondrial amidoxime reducing component 2

1

0

High-throughput

0.458

High

127038

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.458

High

127040

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.458

High

127041

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

127043

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

127044

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.458

High

127047

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.458

High

127048

MFF
Mitochondrial fission factor

1

0

High-throughput

0.458

High

127049

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.458

High

127050

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.458

High

127051

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

127052

MB12B
Multivesicular body subunit 12B

1

0

High-throughput

0.458

High

127053

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.458

High

127055

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.458

High

127056

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

High-throughput

0.458

High

127058

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.458

High

127060

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.458

High

127061

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

127062

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

127063

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.458

High

127065

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

127069

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.458

High

127070

MYH2
Myosin-2

1

0

High-throughput

0.458

High

127071

TAOK2
Serine/threonine-protein kinase TAO2

1

0

High-throughput

0.458

High

127074

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.458

High

127076

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.458

High

127077

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

127078

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

60532

VP37C
Vacuolar protein sorting-associated protein 37C

1

2

High-throughput

0.437

High

127059

S38A7
Sodium-coupled neutral amino acid transporter 7

1

2

High-throughput

0.437

High

127079

FADS3
Fatty acid desaturase 3

1

1

High-throughput

0.437

High

126986

PRAF2
PRA1 family protein 2

1

0

High-throughput

0.249

Low

126990

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.249

Low

126993

COBA1

1

0

High-throughput

0.249

Low

127008

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.249

Low

127015

SLX4I
Protein SLX4IP

1

0

Small-scale

0.249

Low

127020

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.249

Low

127021

CP20A
Cytochrome P450 20A1

1

0

High-throughput

0.249

Low

127023

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.249

Low

127030

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

127037

CC127
Coiled-coil domain-containing protein 127

1

0

High-throughput

0.249

Low

127045

SFXN3
Sideroflexin-3

1

0

High-throughput

0.249

Low

127054

RN121
E3 ubiquitin ligase RNF121

1

0

High-throughput

0.249

Low

127016

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024