Protein: HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)

Gene: HCDH, HADH
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q16836

Gene Ontology (top 5):
GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1163995

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

7

Small-scale

0.647

High

1117741

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.618

High

279775

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

1162345

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1164000

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

253205

RAD1
Cell cycle checkpoint protein RAD1

1

0

High-throughput

0.513

High

1164002

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.513

High

1164014

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.513

High

422205

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

955226

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

1164029

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

61512

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

66209

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

208512

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.479

High

241828

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

281961

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

350879

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

412012

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.479

High

471049

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

519123

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532623

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

588818

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

691763

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.479

High

695591

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

768315

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

828788

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

841761

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

851901

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856275

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

882692

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

934686

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

981509

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

1024055

TFAM
Transcription factor A, mitochondrial

1

3

High-throughput

0.479

High

1048531

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1058043

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1083622

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

1090414

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1114856

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1123299

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1140343

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1163998

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1163999

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

4

High-throughput

0.479

High

1164001

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1164003

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.479

High

1164004

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1164006

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

1164008

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

1164009

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1164012

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1164013

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

2

High-throughput

0.479

High

1164015

MTRFR
Mitochondrial translation release factor in rescue

1

4

High-throughput

0.479

High

1164016

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1164017

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1164018

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1164020

ANLN
Anillin

1

1

High-throughput

0.479

High

1164022

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

4

High-throughput

0.479

High

1164024

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1164026

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

4

High-throughput

0.479

High

1164027

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1164028

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

456073

ADH1A
Alcohol dehydrogenase 1A

1

0

High-throughput

0.460

High

838109

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

High-throughput

0.460

High

1164025

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

138137

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

Small-scale

0.458

High

1161005

FSCN1
Fascin

1

0

High-throughput

0.458

High

1164007

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

1164023

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.458

High

889429

CLK1
Dual specificity protein kinase CLK1

1

2

High-throughput

0.457

High

142346

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

1007704

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.445

High

1164011

OSB11
Oxysterol-binding protein-related protein 11

1

2

High-throughput

0.445

High

1164021

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

128509

RN103
E3 ubiquitin-protein ligase RNF103

1

2

High-throughput

0.437

High

970589

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1015473

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

1163996

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

1

High-throughput

0.437

High

1164010

CARD6
Caspase recruitment domain-containing protein 6

1

2

High-throughput

0.437

High

330169

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

369182

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

598738

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1103973

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

1164005

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.426

High

1163997

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1164019

RTN4
Reticulon-4

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025