HitPredict

Interactor 1: IF2G (P41091)
Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)
Gene: EIF2S3

Interactor 2: IF2G (P41091)
Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)
Gene: EIF2S3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 35271311, 31839598
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains GTP_EFTU~eIF2_C, GTP_EFTU_D2~eIF2_C, GTP_EFTU~GTP_EFTU, GTP_EFTU~GTP_EFTU_D2, GTP_EFTU_D2~GTP_EFTU_D2
Common GO terms GO:0001731 - formation of translation preinitiation complex
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
and 8 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 472
Hs

1 472
+ Sc
+ Hs
+ Sc
+ Sc
+ Sc
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Ec
+ Hs

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Last updated: 11Aug2025