HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25963833, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 136
+	Hs
		832357 MCM2_HUMAN (1-904): 0: 1078: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		832495 MCM2_HUMAN (1-904): 0: 1078: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		832541 MCM2_HUMAN (1-904): 0: 1078: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		935446 MCM2_MOUSE (1-904): 0: 1058: 95.58		H31_MOUSE (1-136): 3.08e-60: 183: 96.32
+	Mm
		952736 MCM2_MOUSE (1-904): 0: 1058: 95.58		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Mm
		952250 MCM2_MOUSE (1-904): 0: 1058: 95.58		H32_MOUSE (1-136): 5.32e-59: 180: 97.06
+	Hs
		828172 MCM2_HUMAN (1-904): 0: 1078: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		708415 MCM4_HUMAN (2-885): 0: 847: 28.42		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		708421 MCM4_HUMAN (2-885): 0: 847: 28.42		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		708398 MCM4_HUMAN (2-885): 0: 847: 28.42		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Sc
		667617 MCM2_YEAST (11-821): 0: 819: 46.70		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		667566 MCM2_YEAST (11-821): 0: 819: 46.70		CENPA_YEAST (18-134): 3.39e-40: 135: 56.67
+	Hs
		708603 MCM5_HUMAN (169-902): 0: 768: 29.43		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		708605 MCM5_HUMAN (169-902): 0: 768: 29.43		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		708661 MCM5_HUMAN (169-902): 0: 768: 29.43		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		708690 MCM5_HUMAN (169-902): 0: 768: 29.43		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		708677 MCM5_HUMAN (169-902): 0: 768: 29.43		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		708683 MCM5_HUMAN (169-902): 0: 768: 29.43		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Sc
		675545 MCM4_YEAST (7-889): 0: 764: 25.82		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		675521 MCM4_YEAST (7-889): 0: 764: 25.82		CENPA_YEAST (18-134): 3.39e-40: 135: 56.67