HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25963833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 904 Hs			1 459
+	Hs
		832430 MCM2_HUMAN (1-904): 0: 1078: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		708436 MCM4_HUMAN (2-885): 0: 847: 28.42		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		832334 MCM2_HUMAN (1-904): 0: 1078: 100.00		FKB1A_HUMAN (149-249): 2.56e-25: 101: 25.71
+	Hs
		708629 MCM5_HUMAN (169-902): 0: 768: 29.43		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		684516 MCM2_HUMAN (1-904): 0: 1078: 100.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		627256 MCM3_HUMAN (186-897): 0: 725: 29.20		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		1035038 MCM8_HUMAN (119-856): 0: 721: 28.81		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		1034852 MCM6_HUMAN (186-817): 0: 710: 31.18		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		708892 MCM7_HUMAN (188-886): 0: 707: 27.35		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		684436 MCM4_HUMAN (2-885): 0: 847: 28.42		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		684437 MCM5_HUMAN (169-902): 0: 768: 29.43		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		627191 MCM3_HUMAN (186-897): 0: 725: 29.20		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		684720 MCM6_HUMAN (186-817): 0: 710: 31.18		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		684438 MCM7_HUMAN (188-886): 0: 707: 27.35		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51