HitPredict

Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Interactor 2: CADH8 (P55286)
Cadherin-8
Gene: CDH8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045296 - cadherin binding GO:0098978 - glutamatergic synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 799
+	Hs
		521809 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH1_HUMAN (33-796): 0: 646: 33.63
+	Mm
		454949 PSN1_MOUSE (1-467): 0: 650: 92.72		CADH1_MOUSE (40-796): 0: 615: 32.78
+	Hs
		834252 PSN1_HUMAN (1-467): 0: 671: 100.00		CAD12_HUMAN (3-486): 2.7e-96: 319: 23.98
+	Hs
		580211 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH2_HUMAN (4-486): 4.15e-64: 232: 21.92
+	Mm
		544700 PSN1_MOUSE (1-467): 0: 650: 92.72		CADH2_MOUSE (4-486): 7.25e-65: 235: 21.86