HitPredict

Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Interactor 2: CAD12 (P55289)
Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)
Gene: CDH12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 794
+	Hs
		834251 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH8_HUMAN (1-791): 0: 781: 54.92
+	Mm
		454949 PSN1_MOUSE (1-467): 0: 650: 92.72		CADH1_MOUSE (30-788): 0: 615: 32.91
+	Hs
		580211 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH2_HUMAN (269-736): 3.74e-37: 151: 16.60
+	Hs
		521809 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH1_HUMAN (2-377): 3.41e-35: 145: 19.70
+	Mm
		544700 PSN1_MOUSE (1-467): 0: 650: 92.72		CADH2_MOUSE (2-302): 3.61e-38: 155: 20.25