HitPredict

Interactor 1: LIS1 (P43034)
Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
Gene: PAFAH1B1

Interactor 2: A16L1 (Q676U5)
Autophagy-related protein 16-1 (APG16-like 1)
Gene: ATG16L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31015422
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005829 - cytosol GO:0021766 - hippocampus development GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 607
+	Hs
		984157 GBB2_HUMAN (166-410): 4.44e-51: 176: 20.48		A16L1_HUMAN (1-607): 2.11e-166: 489: 100.00
+	Hs
		1227562 NLE1_HUMAN (1-219): 1.04e-43: 160: 22.51		A16L1_HUMAN (1-607): 2.11e-166: 489: 100.00
+	Hs
		845264 LIS1_HUMAN (1-410): 1.19e-137: 401: 100.00		WDR5_HUMAN (177-474): 3.11e-58: 200: 17.43
+	Hs
		845250 LIS1_HUMAN (1-410): 1.19e-137: 401: 100.00		LIS1_HUMAN (99-438): 4.66e-48: 175: 14.72
+	Mm
		988931 LIS1_MOUSE (1-410): 9.89e-138: 401: 99.76		LIS1_MOUSE (99-438): 1.04e-47: 174: 14.72
+	Dm
		1463923 FBXW7_DROME (50-403): 1.17e-74: 254: 27.52		WDS_DROME (210-478): 2.84e-57: 198: 18.12
+	Sp
		1068486 TUP12_SCHPO (183-410): 2.84e-56: 196: 26.07		TUP11_SCHPO (24-522): 3.24e-70: 239: 13.97
+	Hs
		222515 PLRG1_HUMAN (224-409): 2.03e-43: 160: 24.73		SNR40_HUMAN (175-514): 4.64e-64: 216: 16.81
+	Hs
		261437 TBL1Y_HUMAN (88-410): 6.8e-80: 257: 23.99		TBL1X_HUMAN (468-607): 8.64e-25: 110: 19.87
+	Hs
		1410246 TBL1Y_HUMAN (88-410): 6.8e-80: 257: 23.99		TBL1R_HUMAN (479-607): 3.68e-24: 108: 18.71
+	Hs
		222461 PLRG1_HUMAN (224-409): 2.03e-43: 160: 24.73		WDR5_HUMAN (177-474): 3.11e-58: 200: 17.43
+	Hs
		965276 NLE1_HUMAN (1-219): 1.04e-43: 160: 22.51		WDR5_HUMAN (177-474): 3.11e-58: 200: 17.43
+	Hs
		984306 GBB2_HUMAN (166-410): 4.44e-51: 176: 20.48		NLE1_HUMAN (441-607): 8.65e-43: 162: 20.34
+	Hs
		983442 GBB2_HUMAN (166-410): 4.44e-51: 176: 20.48		GBB1_HUMAN (165-516): 2.35e-43: 160: 17.18
+	Hs
		1334151 POC1B_HUMAN (179-410): 1.89e-62: 210: 28.88		POC1A_HUMAN (482-607): 3.81e-29: 121: 23.02
+	Hs
		1450936 NLE1_HUMAN (1-219): 1.04e-43: 160: 22.51		NLE1_HUMAN (441-607): 8.65e-43: 162: 20.34
+	Hs
		261440 TBL1R_HUMAN (31-265): 5.9e-56: 193: 22.04		TBL1X_HUMAN (468-607): 8.64e-25: 110: 19.87
+	Mm
		984358 GBB2_MOUSE (166-410): 4.44e-51: 176: 20.48		A16L1_MOUSE (436-605): 1.39e-26: 116: 15.25
+	Hs
		323047 POC1B_HUMAN (179-410): 1.89e-62: 210: 28.88		WDR47_HUMAN (315-396): 9.66e-11: 67: 22.62