HitPredict

Interactor 1: POC1A (Q8NBT0)
POC1 centriolar protein homolog A (Pix2) (Proteome of centriole protein 1A) (WD repeat-containing protein 51A)
Gene: POC1A

Interactor 2: POC1B (Q8TC44)
POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B)
Gene: POC1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	26186194, 26638075, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000922 - spindle pole GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005814 - centriole GO:0036064 - ciliary basal body and 1 others more... GO:0060271 - cilium assembly
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 478
+	Hs
		1380064 FBXW7_HUMAN (131-399): 1.14e-64: 221: 21.32		FBXW7_HUMAN (171-456): 1.1e-54: 196: 16.50
+	Dm
		1463899 WDS_DROME (259-406): 1.13e-32: 127: 14.77		WDS_DROME (132-443): 1.6e-89: 278: 20.19
+	Hs
		1450936 NLE1_HUMAN (308-403): 1.75e-20: 95.1: 10.31		NLE1_HUMAN (1-255): 4.01e-70: 232: 22.44
+	Hs
		965141 FBXW7_HUMAN (131-399): 1.14e-64: 221: 21.32		WDR5_HUMAN (300-443): 1.63e-23: 102: 9.59
+	Hs
		209154 PRP4_HUMAN (131-405): 4.33e-60: 204: 16.49		PRP4_HUMAN (214-417): 4.14e-25: 109: 17.29
+	Hs
		209230 PRP4_HUMAN (131-405): 4.33e-60: 204: 16.49		WDR5_HUMAN (300-443): 1.63e-23: 102: 9.59
+	Hs
		209318 PRP4_HUMAN (131-405): 4.33e-60: 204: 16.49		SNR40_HUMAN (312-444): 7.5e-19: 89.9: 8.09
+	Hs
		597338 GBB3_HUMAN (7-173): 7.86e-33: 128: 25.29		GBB3_HUMAN (6-172): 5.65e-35: 135: 24.71
+	Hs
		845346 LIS1_HUMAN (265-407): 2.29e-30: 122: 12.25		KTNB1_HUMAN (12-180): 4.34e-25: 110: 34.91
+	Hs
		965071 WDR5B_HUMAN (259-406): 7.48e-32: 125: 16.78		WDR5_HUMAN (300-443): 1.63e-23: 102: 9.59
+	Hs
		845264 LIS1_HUMAN (265-407): 2.29e-30: 122: 12.25		WDR5_HUMAN (300-443): 1.63e-23: 102: 9.59
+	Hs
		845250 LIS1_HUMAN (265-407): 2.29e-30: 122: 12.25		LIS1_HUMAN (313-471): 5.29e-22: 99.9: 9.32
+	Mm
		988931 LIS1_MOUSE (265-407): 1.92e-30: 122: 12.25		LIS1_MOUSE (313-471): 4.56e-22: 99.9: 9.32
+	Hs
		965151 SNR40_HUMAN (263-403): 5.65e-29: 117: 15.39		WDR5_HUMAN (300-443): 1.63e-23: 102: 9.59
+	Sp
		1068482 TUP11_SCHPO (254-400): 1.96e-27: 116: 14.77		TUP11_SCHPO (324-443): 6.46e-18: 88.7: 10.94
+	Hs
		965276 NLE1_HUMAN (308-403): 1.75e-20: 95.1: 10.31		WDR5_HUMAN (300-443): 1.63e-23: 102: 9.59
+	Sp
		1068486 TUP11_SCHPO (254-400): 1.96e-27: 116: 14.77		TUP12_SCHPO (297-441): 2.03e-15: 80.6: 9.15
+	Sc
		673545 NLE1_YEAST (6-88): 8.87e-21: 95.8: 34.94		NLE1_YEAST (312-444): 1.94e-19: 92.9: 11.51
+	Hs
		984306 NLE1_HUMAN (308-403): 1.75e-20: 95.1: 10.31		GBB2_HUMAN (180-358): 2.14e-19: 91.2: 16.39