HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: MYLIP (Q8WY64)
E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)
Gene: MYLIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	29707137, 21685362, 21734303
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 445
+	Hs
		1264347 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00
+	Hs
		919803 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00
+	Hs
		895861 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00
+	Hs
		896505 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00