HitPredict

Interactor 1: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Interactor 2: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	20153263, 21030982, 15221006
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AF-4~AF-4, AF-4_C~AF-4_C
Common GO terms	GO:0008023 - transcription elongation factor complex GO:0010468 - regulation of gene expression GO:0032783 - super elongation complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1210
+	Hs
		850828 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44
+	Hs
		850820 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		Q8TD98_HUMAN (213-831): 1.77e-38: 155: 74.04
+	Hs
		1231733 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42
+	Hs
		1154038 NIPBL_HUMAN (12-1005): 1.12e-50: 199: 12.27		NIPBL_HUMAN (12-1005): 1.12e-50: 199: 12.27
+	Hs
		1126898 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		AN36C_HUMAN (375-1142): 1.33e-47: 189: 13.24
+	Hs
		1231748 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		MINT_HUMAN (70-744): 7.76e-09: 62.7: 10.13
+	Hs
		1329244 TARA_HUMAN (19-1006): 9.21e-18: 91.7: 7.94		TARA_HUMAN (19-1006): 9.21e-18: 91.7: 7.94
+	Mm
		1351630 PCLO_MOUSE (6-989): 7.06e-16: 85.9: 10.27		PCLO_MOUSE (6-989): 7.06e-16: 85.9: 10.27
+	Dm
		1376672 FUTSC_DROME (18-979): 6.66e-12: 72.6: 11.09		FUTSC_DROME (18-979): 6.66e-12: 72.6: 11.09
+	Hs
		152645 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55
+	Hs
		1056827 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79
+	Hs
		1056876 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		MICA3_HUMAN (92-811): 7.34e-10: 65.8: 11.23
+	Hs
		1057757 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55
+	hg
		2814 A0A0C7TIF2_EBVG (90-773): 4.62e-09: 63.1: 16.19		A0A0C7TIF2_EBVG (90-773): 4.62e-09: 63.1: 16.19
+	Dm
		113976 M9PB30_DROME (27-449): 7.87e-09: 62.8: 10.82		M9PB30_DROME (27-449): 7.87e-09: 62.8: 10.82