HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25659891, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 603 Hs			1 716
+	Hs
		150689 PLK1_HUMAN (1-603): 0: 617: 100.00		DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66
+	Hs
		150919 PLK1_HUMAN (1-603): 0: 617: 100.00		DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13
+	Ce
		711481 PLK1_CAEEL (22-599): 0: 536: 50.58		Q18239_CAEEL (4-626): 4.09e-89: 297: 31.14
+	Hs
		150707 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66
+	Hs
		861765 PLK1_HUMAN (1-603): 0: 617: 100.00		DIXC1_HUMAN (4-85): 2.43e-30: 129: 38.55
+	Hs
		861861 PLK1_HUMAN (1-603): 0: 617: 100.00		PARD3_HUMAN (200-415): 1.34e-19: 96.2: 20.00
+	Ce
		1093973 PLK3_CAEEL (23-591): 4.14e-157: 465: 39.14		MIG5_CAEEL (2-545): 2.14e-57: 208: 26.29
+	Ce
		711456 PLK1_CAEEL (22-599): 0: 536: 50.58		PAR3_CAEEL (79-708): 2.88e-13: 75.9: 14.81
+	Rn
		291511 PLK2_RAT (6-587): 1.9e-166: 492: 35.43		MAGI2_RAT (110-382): 2.75e-17: 88.8: 13.31
+	Mm
		1143553 KS6A2_MOUSE (1-367): 4.69e-110: 348: 23.48		DLG4_MOUSE (91-649): 6.72e-43: 167: 13.22
+	Hs
		942348 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		DLG4_HUMAN (91-649): 2.13e-42: 166: 13.19
+	Hs
		1021498 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		DLG1_HUMAN (113-656): 1.76e-42: 167: 14.34
+	Hs
		1073454 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		PAR3L_HUMAN (69-352): 9.93e-22: 103: 19.24
+	Hs
		1049960 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		SCRIB_HUMAN (238-648): 1.84e-17: 89.4: 17.49
+	Hs
		1073444 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		MAGI2_HUMAN (68-649): 2.11e-17: 89.2: 9.72
+	Hs
		1073470 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		MAGI1_HUMAN (124-664): 2.49e-17: 89.2: 10.86
+	Hs
		1049957 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		SCRIB_HUMAN (238-648): 1.84e-17: 89.4: 17.49
+	Hs
		1073453 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		LNX1_HUMAN (127-369): 3.42e-14: 78.4: 17.07
+	Hs
		850651 KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44		SCRIB_HUMAN (238-648): 1.84e-17: 89.4: 17.49
+	Hs
		883917 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		SYJ2B_HUMAN (247-322): 4.13e-14: 71.8: 33.75