HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: Q5TBB8 (Q5TBB8)
Lysosomal associated multispanning membrane protein 5, isoform CRA_a (Lysosomal multispanning membrane protein 5) (cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNA)
Gene: LAPTM5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21765395
Identification Methods	peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006622 - protein targeting to lysosome GO:0019899 - enzyme binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 262
+	Hs
		861597 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		LAPM5_HUMAN (1-262): 2.04e-151: 424: 100.00
+	Hs
		1110932 WWP1_HUMAN (385-707): 7.2e-57: 216: 17.48		LAPM5_HUMAN (1-262): 2.04e-151: 424: 100.00
+	Hs
		132018 WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79		LAPM5_HUMAN (1-262): 2.04e-151: 424: 100.00
+	Hs
		1110929 NED4L_HUMAN (424-676): 1.65e-30: 133: 16.55		LAPM5_HUMAN (1-262): 2.04e-151: 424: 100.00
+	Hs
		1110928 ITCH_HUMAN (305-642): 6.68e-25: 114: 14.82		LAPM5_HUMAN (1-262): 2.04e-151: 424: 100.00
+	Hs
		1110935 SMUF2_HUMAN (485-719): 4.19e-24: 111: 18.55		LAPM5_HUMAN (1-262): 2.04e-151: 424: 100.00
+	Mm
		861877 NEDD4_MOUSE (433-678): 5.12e-22: 105: 15.51		LAPM5_MOUSE (1-262): 4.29e-144: 405: 79.01