HitPredict

Interactor 1: NEDD4 (P46935)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: TMG2 (Q8R182)
Transmembrane gamma-carboxyglutamic acid protein 2 (NEDD4 WW domain-binding protein 1) (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2)
Gene: Prrg2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	11042109
Identification Methods	far western blotting, affinity technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 887 Mm			1 198
+	Hs
		160942 NED4L_HUMAN (70-887): 0: 778: 56.22		TMG2_HUMAN (1-198): 1.29e-84: 250: 76.70
+	Hs
		1400006 NED4L_HUMAN (70-887): 0: 778: 56.22		TMG4_HUMAN (10-191): 6.75e-70: 213: 38.38
+	Hs
		160933 NED4L_HUMAN (70-887): 0: 778: 56.22		TMG1_HUMAN (32-194): 1.52e-53: 172: 31.34
+	Hs
		861763 NEDD4_HUMAN (157-887): 0: 735: 79.83		TMG4_HUMAN (10-191): 6.75e-70: 213: 38.38
+	Hs
		1394603 ITCH_HUMAN (67-884): 0: 700: 31.24		TMG4_HUMAN (10-191): 6.75e-70: 213: 38.38
+	Hs
		1400007 NED4L_HUMAN (70-887): 0: 778: 56.22		TMG3_HUMAN (30-151): 8.02e-38: 132: 34.40
+	Hs
		160926 NEDD4_HUMAN (157-887): 0: 735: 79.83		TMG1_HUMAN (32-194): 1.52e-53: 172: 31.34
+	Hs
		1419615 WWP1_HUMAN (65-884): 0: 674: 31.17		TMG4_HUMAN (10-191): 6.75e-70: 213: 38.38
+	Hs
		160932 ITCH_HUMAN (67-884): 0: 700: 31.24		TMG1_HUMAN (32-194): 1.52e-53: 172: 31.34
+	Hs
		861764 NEDD4_HUMAN (157-887): 0: 735: 79.83		TMG3_HUMAN (30-151): 8.02e-38: 132: 34.40
+	Hs
		160934 WWP1_HUMAN (65-884): 0: 674: 31.17		TMG1_HUMAN (32-194): 1.52e-53: 172: 31.34
+	Hs
		1260710 HECW1_HUMAN (7-396): 2.2e-18: 93: 13.69		TMG4_HUMAN (10-191): 6.75e-70: 213: 38.38
+	Hs
		160935 HECW2_HUMAN (13-511): 4.48e-19: 95.3: 12.23		TMG1_HUMAN (32-194): 1.52e-53: 172: 31.34
+	Hs
		160930 HECW1_HUMAN (7-396): 2.2e-18: 93: 13.69		TMG1_HUMAN (32-194): 1.52e-53: 172: 31.34