Protein: TMG4
Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4)

Gene: TMG4, PRRG4
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q9BZD6

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007596 - blood coagulation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

862426

YAP1
Transcriptional coactivator YAP1

6

18

Small-scale

0.740

High

861763

NEDD4
E3 ubiquitin-protein ligase NEDD4

5

14

Small-scale

0.720

High

1401110

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

2

2

Small-scale

0.629

High

1257295

STXB4
Syntaxin-binding protein 4

3

1

High-throughput

0.609

High

1394603

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

14

Small-scale

0.602

High

1419614

WWTR1
WW domain-containing transcription regulator protein 1

1

20

Small-scale

0.589

High

1400006

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

14

Small-scale

0.583

High

641670

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

3

High-throughput

0.576

High

1145775

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

3

High-throughput

0.576

High

1215977

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

4

Small-scale

0.561

High

520995

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.541

High

585461

VEGFA
Vascular endothelial growth factor A, long form

1

2

High-throughput

0.541

High

440717

FYN
Tyrosine-protein kinase Fyn

1

6

Small-scale

0.536

High

463745

LYN
Tyrosine-protein kinase Lyn

1

6

Small-scale

0.536

High

473470

HCK
Tyrosine-protein kinase HCK

1

6

Small-scale

0.536

High

840895

TEC
Tyrosine-protein kinase Tec

1

6

Small-scale

0.536

High

840983

ABL2
Tyrosine-protein kinase ABL2

1

6

Small-scale

0.536

High

913676

VAV2
Guanine nucleotide exchange factor VAV2

1

4

Small-scale

0.536

High

987919

GRB2
Growth factor receptor-bound protein 2

1

8

Small-scale

0.536

High

1111770

GRAP
GRB2-related adapter protein

1

8

Small-scale

0.536

High

1154166

ITSN1
Intersectin-1

1

2

Small-scale

0.536

High

1288690

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

2

Small-scale

0.536

High

1370977

PEX13
Peroxisomal membrane protein PEX13

1

1

Small-scale

0.536

High

1419615

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

14

Small-scale

0.536

High

800231

VKGC
Vitamin K-dependent gamma-carboxylase

1

2

High-throughput

0.536

High

1164224

AOC3
Amine oxidase [copper-containing] 3

1

0

High-throughput

0.518

High

1315841

AN13A
Ankyrin repeat domain-containing protein 13A

1

0

High-throughput

0.513

High

1054141

BTK
Tyrosine-protein kinase BTK

1

6

Small-scale

0.501

High

1110050

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.494

High

302207

NEBL
Nebulette

1

1

Small-scale

0.489

High

1121978

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

Small-scale

0.489

High

1260710

HECW1
E3 ubiquitin-protein ligase HECW1

1

14

Small-scale

0.489

High

1369902

OSTF1
Osteoclast-stimulating factor 1

1

2

Small-scale

0.489

High

557455

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

Small-scale

0.479

High

1051049

FAK1
Focal adhesion kinase 1

1

5

Small-scale

0.479

High

353898

BCL10
B-cell lymphoma/leukemia 10

1

0

High-throughput

0.282

High

957661

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.282

High

1406588

CTIP
DNA endonuclease RBBP8

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025