HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: RAI14 (Q9P0K7)
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)
Gene: RAI14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	26186194, 28514442, 25659891, 33961781, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 980
+	Hs
		861831 PLK1_HUMAN (1-603): 0: 617: 100.00		MIB1_HUMAN (1-552): 5.8e-59: 221: 18.56
+	Hs
		861724 PLK1_HUMAN (1-603): 0: 617: 100.00		ANK3_HUMAN (24-405): 2.11e-47: 187: 18.74
+	Hs
		861845 PLK1_HUMAN (1-603): 0: 617: 100.00		ANR44_HUMAN (5-217): 4.63e-46: 181: 26.77
+	Hs
		1268102 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		MY18A_HUMAN (351-942): 3.03e-73: 267: 19.06
+	Hs
		861846 PLK1_HUMAN (1-603): 0: 617: 100.00		ANR52_HUMAN (122-358): 5.33e-22: 104: 18.57
+	Hs
		166901 PLK1_HUMAN (1-603): 0: 617: 100.00		ANR28_HUMAN (156-405): 1.15e-12: 74.2: 14.00
+	Hs
		1237557 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		ANR44_HUMAN (5-217): 4.63e-46: 181: 26.77
+	Hs
		167024 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		ANR28_HUMAN (156-405): 1.15e-12: 74.2: 14.00
+	Hs
		128963 PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70		POTEI_HUMAN (16-586): 3.08e-65: 241: 18.50
+	Hs
		129024 PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70		MIB1_HUMAN (1-552): 5.8e-59: 221: 18.56
+	Hs
		980378 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Hs
		160648 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		MIB1_HUMAN (1-552): 5.8e-59: 221: 18.56
+	Hs
		160716 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		EHMT2_HUMAN (57-424): 2.35e-45: 180: 14.71
+	Dr
		94576 F1RB74_DANRE (58-306): 4.93e-53: 197: 40.00		MIB1_DANRE (1-158): 1.25e-21: 103: 20.96