Protein: TSYL1
Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1)

Gene: TSYL1, TSPYL1
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q9H0U9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1430539

TSYL2
Testis-specific Y-encoded-like protein 2

5

17

High-throughput

0.926

High

1404324

NP1L3
Nucleosome assembly protein 1-like 3

3

17

High-throughput

0.855

High

1430550

TSYL4
Testis-specific Y-encoded-like protein 4

2

16

High-throughput

0.811

High

1430553

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

5

4

High-throughput

0.722

High

848348

MAGA4
Melanoma-associated antigen 4

5

7

High-throughput

0.713

High

998012

CSK21
Casein kinase II subunit alpha

4

20

High-throughput

0.704

High

1428534

DDX24
ATP-dependent RNA helicase DDX24

4

6

High-throughput

0.697

High

1430556

SNX6
Sorting nexin-6

4

1

High-throughput

0.697

High

1029383

SET
Protein SET

1

14

High-throughput

0.691

High

1430554

NP1L2
Nucleosome assembly protein 1-like 2

1

18

High-throughput

0.691

High

1143526

PCM1
Pericentriolar material 1 protein

5

0

High-throughput

0.679

High

960557

PSME3
Proteasome activator complex subunit 3

3

2

High-throughput

0.675

High

1323537

ZN687
Zinc finger protein 687

3

3

High-throughput

0.675

High

1430551

AKA11
A-kinase anchor protein 11

3

0

High-throughput

0.634

High

396915

ESR1
Estrogen receptor

3

9

High-throughput

0.633

High

1291359

LCA5
Lebercilin

2

5

High-throughput

0.628

High

1430538

TSYL1
Testis-specific Y-encoded-like protein 1

1

14

High-throughput

0.621

High

419196

H2A1B
Histone H2A type 1-B/E

1

14

High-throughput

0.618

High

754984

H2B1B
Histone H2B type 1-B

1

19

High-throughput

0.618

High

423133

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.602

High

1314413

SLX4
Structure-specific endonuclease subunit SLX4

2

0

High-throughput

0.585

High

906349

GPC3
Glypican-3

2

1

High-throughput

0.574

High

1037636

RL18A
Large ribosomal subunit protein eL20

2

1

High-throughput

0.574

High

1290717

ZCH18
Zinc finger CCCH domain-containing protein 18

2

4

High-throughput

0.574

High

1366093

K0232
Uncharacterized protein KIAA0232

2

1

High-throughput

0.574

High

1388053

TRI44
Tripartite motif-containing protein 44

2

2

High-throughput

0.574

High

1401162

SPAG5
Sperm-associated antigen 5

2

3

High-throughput

0.574

High

1430549

SI1L2
Signal-induced proliferation-associated 1-like protein 2

2

1

High-throughput

0.574

High

1348954

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.549

High

159847

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.536

High

287129

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

2

High-throughput

0.536

High

331312

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.536

High

447424

NPM
Nucleophosmin

1

2

High-throughput

0.536

High

625616

CSK22
Casein kinase II subunit alpha'

1

17

High-throughput

0.536

High

686417

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

872733

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

960882

RL15
Large ribosomal subunit protein eL15

1

6

High-throughput

0.536

High

970100

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

985331

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.536

High

986198

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.536

High

1097734

STK3
Serine/threonine-protein kinase 3

1

1

High-throughput

0.536

High

1313145

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

1

High-throughput

0.536

High

1406983

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.536

High

1430540

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

290724

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

1039391

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.513

High

1383849

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1430546

RBM28
RNA-binding protein 28

1

0

High-throughput

0.513

High

186014

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

774610

BASI
Basigin

1

2

High-throughput

0.489

High

1206625

AMER1
APC membrane recruitment protein 1

1

1

High-throughput

0.489

High

1246981

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.489

High

1430558

NPTN
Neuroplastin

1

2

High-throughput

0.489

High

215185

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

1

High-throughput

0.481

High

928224

HAP1
Huntingtin-associated protein 1

1

2

High-throughput

0.481

High

954908

PSA6
Proteasome subunit alpha type-6

1

1

High-throughput

0.481

High

1252776

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.481

High

1371433

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

3

High-throughput

0.481

High

1380962

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

2

High-throughput

0.481

High

1385300

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

4

High-throughput

0.481

High

1407083

MDFI
MyoD family inhibitor

1

2

High-throughput

0.481

High

1430547

GPT2L
G patch domain-containing protein 2-like

1

1

High-throughput

0.481

High

182365

WDR46
WD repeat-containing protein 46

1

4

High-throughput

0.479

High

194340

R113A
E3 ubiquitin-protein ligase RNF113A

1

2

High-throughput

0.479

High

242881

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

316000

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

316982

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.479

High

674326

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.479

High

800094

COIL
Coilin

1

1

High-throughput

0.479

High

810364

RL3
Large ribosomal subunit protein uL3

1

3

High-throughput

0.479

High

854931

RECQ1
ATP-dependent DNA helicase Q1

1

5

High-throughput

0.479

High

937903

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

980302

H4
Histone H4

1

4

High-throughput

0.479

High

995259

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

1024178

TFAM
Transcription factor A, mitochondrial

1

5

High-throughput

0.479

High

1040920

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

1114264

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1141300

BRD3
Bromodomain-containing protein 3

1

15

High-throughput

0.479

High

1352744

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1367235

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1368612

KAT6A
Histone acetyltransferase KAT6A

1

6

High-throughput

0.479

High

1370578

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.479

High

1388724

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

3

Small-scale

0.479

High

1397417

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1415812

KIFC1
Kinesin-like protein KIFC1

1

1

High-throughput

0.479

High

1428462

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

1430543

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1430555

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

693973

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

1089013

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1430548

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1395343

CC136
Coiled-coil domain-containing protein 136

1

2

High-throughput

0.439

High

294310

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1249203

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1430542

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1430544

RC3H2
Roquin-2

1

4

High-throughput

0.437

High

1430552

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

606035

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.426

High

58930

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

2

High-throughput

0.407

High

1230932

WWC2
Protein WWC2

1

4

High-throughput

0.407

High

1430541

OSBL3
Oxysterol-binding protein-related protein 3

3

0

High-throughput

0.345

High

1253935

FA83H
Protein FAM83H

2

0

High-throughput

0.328

High

1386103

EVI5L
EVI5-like protein

2

0

High-throughput

0.328

High

1430545

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

391455

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

231010

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

469544

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

760498

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

986915

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

0

High-throughput

0.279

Low

1012610

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.279

Low

1208330

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

1232914

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

0

High-throughput

0.279

Low

1322506

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1397245

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

1430557

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low

1124906

FLOT2
Flotillin-2

1

0

High-throughput

0.249

Low

379806

IGHD
Immunoglobulin heavy constant delta

1

0

High-throughput

0.232

Low

1417613

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025