HitPredict

Interactor 1: C1C3F8 (C1C3F8)
LP16188p
Gene: Rpt4-RA

Interactor 2: Q9V3V6 (Q9V3V6)
26S proteasome regulatory complex subunit p50 (GH12068p) (Regulatory particle triple-A ATPase 5 (EC 3.-.-.-, EC 3.6.1.3))
Gene: Rpt5

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.770

Property	Details
Experiments	unassigned1513, unassigned2874
Identification Methods	two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB, AAA_lid_3~AAA_lid_3, Prot_ATP_ID_OB~Prot_ATP_ID_OB
Common GO terms	GO:0005524 - ATP binding GO:0008540 - proteasome regulatory particle, base subcomplex GO:0016887 - ATP hydrolysis activity GO:0036402 - proteasome-activating activity GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 406 Dm			1 428
+	Hs
		92617 PRS10_HUMAN (22-406): 1.19e-135: 395: 89.35		E9PMD8_HUMAN (14-283): 2.29e-160: 455: 85.56
+	Dm
		820534 Q9W414_DROME (10-406): 2.57e-137: 399: 100.00		PRS4_DROME (33-422): 2.02e-152: 440: 45.94
+	Dm
		820493 Q8SZ19_DROME (10-406): 7.4e-137: 398: 99.50		PRS4_DROME (33-422): 2.02e-152: 440: 45.94
+	Hs
		906805 PRS10_HUMAN (22-406): 1.19e-135: 395: 89.35		PRS4_HUMAN (23-422): 3.35e-153: 442: 44.80
+	At
		1352073 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		PS6AA_ARATH (16-428): 1.1e-129: 382: 75.36
+	At
		137842 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		PS6AB_ARATH (16-428): 2.99e-126: 373: 74.88
+	At
		1319804 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		PRS8A_ARATH (48-427): 7.97e-124: 367: 43.19
+	At
		1352076 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		PRS6B_ARATH (10-427): 8.42e-119: 354: 36.60
+	Dm
		1359242 Q9W414_DROME (10-406): 2.57e-137: 399: 100.00		Q9V3V6_DROME (1-428): 1.03e-133: 392: 100.00
+	At
		1353078 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		PRS4A_ARATH (43-421): 1.88e-110: 333: 46.44
+	Dm
		1376592 Q9W414_DROME (10-406): 2.57e-137: 399: 100.00		Q9W414_DROME (46-421): 3.74e-130: 382: 42.02
+	At
		1352513 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		PRS4B_ARATH (43-421): 1.61e-109: 331: 46.17
+	Hs
		572919 PRS10_HUMAN (22-406): 1.19e-135: 395: 89.35		PRS6A_HUMAN (12-428): 3.45e-130: 384: 85.37
+	Hs
		906979 PRS10_HUMAN (22-406): 1.19e-135: 395: 89.35		PRS8_HUMAN (48-426): 2.9e-130: 383: 45.00
+	Dm
		1359423 Q9W414_DROME (10-406): 2.57e-137: 399: 100.00		Q9V405_DROME (1-427): 1.96e-119: 355: 37.85
+	Dm
		186171 Q9W414_DROME (10-406): 2.57e-137: 399: 100.00		PRS8_DROME (48-427): 8.71e-119: 354: 43.83
+	Dm
		186125 Q8SZ19_DROME (10-406): 7.4e-137: 398: 99.50		PRS8_DROME (48-427): 8.71e-119: 354: 43.83
+	Hs
		798635 PRS10_HUMAN (22-406): 1.19e-135: 395: 89.35		PRS6B_HUMAN (1-427): 7.07e-119: 354: 38.19
+	At
		870963 PRS4A_ARATH (3-397): 5.97e-156: 449: 42.64		CD48A_ARATH (161-408): 3.88e-81: 267: 39.52