Protein: GIT2
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)

Gene: GIT2
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q14161

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005654 - nucleoplasm
GO:0005925 - focal adhesion
GO:0007420 - brain development
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121947

ARHG7
Rho guanine nucleotide exchange factor 7

7

20

Small-scale

0.966

High

1122391

ARHG6
Rho guanine nucleotide exchange factor 6

6

20

High-throughput

0.946

High

1096431

PAK1
Serine/threonine-protein kinase PAK 1

6

15

Small-scale

0.938

High

878456

PAXI
Paxillin

6

20

Small-scale

0.935

High

1122465

GIT1
ARF GTPase-activating protein GIT1

5

14

Small-scale

0.930

High

253951

LPXN
Leupaxin

3

20

High-throughput

0.855

High

1097191

PAK2
Serine/threonine-protein kinase PAK 2

3

13

High-throughput

0.855

High

1122397

KCC4
Calcium/calmodulin-dependent protein kinase type IV

2

10

High-throughput

0.811

High

1122454

SPN90
NCK-interacting protein with SH3 domain

2

2

High-throughput

0.811

High

222081

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.797

High

593994

NCK1
SH2/SH3 adapter protein NCK1

4

20

High-throughput

0.783

High

955159

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

1122466

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.764

High

329063

KLHL2
Kelch-like protein 2

2

4

High-throughput

0.705

High

227556

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.698

High

625375

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.691

High

992172

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.691

High

1122464

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

15

High-throughput

0.691

High

921535

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

1

High-throughput

0.667

High

1122461

MAFF
Transcription factor MafF

3

2

High-throughput

0.667

High

427896

ICAM1
Intercellular adhesion molecule 1

2

8

High-throughput

0.628

High

767529

RECO
Recoverin

1

1

High-throughput

0.625

High

1122396

IKBB
NF-kappa-B inhibitor beta

1

18

High-throughput

0.625

High

1122387

GIT2
ARF GTPase-activating protein GIT2

1

15

Small-scale

0.621

High

1122449

SHLB2
Endophilin-B2

1

9

High-throughput

0.621

High

581042

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

669131

ARBK1
Beta-adrenergic receptor kinase 1

1

8

Small-scale

0.618

High

988361

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015433

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1122407

PKN3
Serine/threonine-protein kinase N3

1

12

High-throughput

0.618

High

1122409

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1122411

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1122424

FBXW7
F-box/WD repeat-containing protein 7

1

11

High-throughput

0.618

High

966305

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

1049283

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

1122394

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

High-throughput

0.601

High

1122390

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.582

High

1122413

GET4
Golgi to ER traffic protein 4 homolog

2

0

High-throughput

0.580

High

1122442

SYNCI
Syncoilin

2

6

High-throughput

0.574

High

1122450

EXOC1
Exocyst complex component 1

2

4

High-throughput

0.574

High

1122451

FBX28
F-box only protein 28

2

1

High-throughput

0.574

High

1122455

TMOD4
Tropomodulin-4

2

8

High-throughput

0.574

High

1093814

TRAF1
TNF receptor-associated factor 1

1

2

High-throughput

0.573

High

1122395

TSN
Translin

1

0

High-throughput

0.558

High

1122448

MED4
Mediator of RNA polymerase II transcription subunit 4

1

4

High-throughput

0.554

High

126593

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.553

High

601287

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

953443

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.553

High

1122403

PHLB3
Pleckstrin homology-like domain family B member 3

1

7

High-throughput

0.553

High

1122406

FBX42
F-box only protein 42

1

5

High-throughput

0.553

High

1122429

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1122439

KLHL4
Kelch-like protein 4

1

5

High-throughput

0.553

High

1122440

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

1122441

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

1122444

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.553

High

167510

TX1B3
Tax1-binding protein 3

2

20

High-throughput

0.549

High

261802

PFD1
Prefoldin subunit 1

2

1

High-throughput

0.549

High

1122408

TM154
Transmembrane protein 154

2

1

High-throughput

0.549

High

1122434

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.549

High

634436

LMNB1
Lamin-B1

1

5

High-throughput

0.541

High

1014510

SMAD3
Mothers against decapentaplegic homolog 3

1

7

High-throughput

0.541

High

1122388

E2F2
Transcription factor E2F2

1

6

High-throughput

0.541

High

1122462

UBQL1
Ubiquilin-1

1

3

High-throughput

0.541

High

211641

ZNHI1
Zinc finger HIT domain-containing protein 1

1

1

High-throughput

0.536

High

1122222

SCRIB
Protein scribble homolog

1

17

High-throughput

0.536

High

1122412

CENPQ
Centromere protein Q

1

1

High-throughput

0.536

High

721716

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.518

High

1122422

PROX1
Prospero homeobox protein 1

1

0

High-throughput

0.518

High

1122443

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.518

High

94310

D6R9G5
Kelch like family member 2

1

6

High-throughput

0.514

High

219170

LTOR5
Ragulator complex protein LAMTOR5

1

1

High-throughput

0.494

High

1122453

KCTD5
BTB/POZ domain-containing protein KCTD5

1

16

High-throughput

0.494

High

1122438

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.489

High

555682

ACTN1
Alpha-actinin-1

1

20

High-throughput

0.481

High

639240

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

13

High-throughput

0.481

High

993173

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.481

High

1095624

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

18

High-throughput

0.481

High

1121663

SAFB2
Scaffold attachment factor B2

1

7

High-throughput

0.481

High

1122405

EDC4
Enhancer of mRNA-decapping protein 4

1

6

High-throughput

0.481

High

1122416

RUSC2
AP-4 complex accessory subunit RUSC2

1

1

High-throughput

0.481

High

1122433

RUFY1
RUN and FYVE domain-containing protein 1

1

9

High-throughput

0.481

High

1122435

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

5

High-throughput

0.481

High

1122463

ATF5
Cyclic AMP-dependent transcription factor ATF-5

1

3

High-throughput

0.481

High

1122467

PCLO
Protein piccolo

1

15

Small-scale

0.481

High

132725

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

3

High-throughput

0.479

High

192920

CLOCK
Circadian locomoter output cycles protein kaput

1

3

High-throughput

0.479

High

437168

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

459587

PROF1
Profilin-1

1

3

High-throughput

0.479

High

503580

TFPT
TCF3 fusion partner

1

1

High-throughput

0.479

High

959578

MAX
Protein max

1

9

High-throughput

0.479

High

1122393

RABE1
Rab GTPase-binding effector protein 1

1

9

High-throughput

0.479

High

1122398

GRAP1
GRIP1-associated protein 1

1

9

High-throughput

0.479

High

1122415

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

10

High-throughput

0.479

High

1122418

PSD4
PH and SEC7 domain-containing protein 4

1

9

High-throughput

0.479

High

1122419

GOGA5
Golgin subfamily A member 5

1

13

High-throughput

0.479

High

1122421

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.479

High

1122426

PF21A
PHD finger protein 21A

1

6

High-throughput

0.479

High

1122431

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

1122437

NUF2
Kinetochore protein Nuf2

1

10

High-throughput

0.479

High

1122456

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1122459

RABX5
Rab5 GDP/GTP exchange factor

1

1

High-throughput

0.479

High

1122460

RCOR1
REST corepressor 1

1

6

High-throughput

0.479

High

217089

MS18B
Protein Mis18-beta

1

0

High-throughput

0.458

High

340324

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

1122404

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1122427

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1122436

YJU2
Splicing factor YJU2

1

0

High-throughput

0.458

High

690995

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

729827

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

1122410

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.445

High

1122432

CK5P2
CDK5 regulatory subunit-associated protein 2

1

19

High-throughput

0.445

High

399502

C4BPA
C4b-binding protein alpha chain

1

1

High-throughput

0.439

High

436863

K1C18
Keratin, type I cytoskeletal 18

1

4

High-throughput

0.439

High

648155

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.439

High

724389

COR1A
Coronin-1A

1

17

High-throughput

0.439

High

1122392

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

2

High-throughput

0.439

High

1122417

USBP1
Harmonin-binding protein USHBP1

1

7

High-throughput

0.439

High

85258

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

1

High-throughput

0.437

High

128428

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.437

High

345804

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.437

High

1122399

EIPR1
EARP and GARP complex-interacting protein 1

1

6

High-throughput

0.437

High

1122400

CCD93
Coiled-coil domain-containing protein 93

1

6

High-throughput

0.437

High

1122402

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.437

High

1122414

HAUS6
HAUS augmin-like complex subunit 6

1

1

High-throughput

0.437

High

1122420

CCHCR
Coiled-coil alpha-helical rod protein 1

1

11

High-throughput

0.437

High

1122425

VP33A
Vacuolar protein sorting-associated protein 33A

1

4

High-throughput

0.437

High

1122430

SNX27
Sorting nexin-27

1

20

High-throughput

0.437

High

1122445

NCK5L
Nck-associated protein 5-like

1

3

High-throughput

0.437

High

1122446

TUFT1
Tuftelin

1

2

High-throughput

0.437

High

1122447

HM20A
High mobility group protein 20A

1

6

High-throughput

0.437

High

1122457

OPN4
Melanopsin

1

1

High-throughput

0.437

High

1122458

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

1

High-throughput

0.437

High

467829

BGLR
Beta-glucuronidase

1

0

High-throughput

0.282

High

1122423

HGD
Homogentisate 1,2-dioxygenase

1

0

High-throughput

0.282

High

1122452

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.279

Low

1122389

MVP
Major vault protein

1

0

High-throughput

0.251

Low

539056

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.249

Low

1122401

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

1122428

VPS50
Syndetin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025