HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	37349645, 30405104, 30442713
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0035019 - somatic stem cell population maintenance
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 759
+	Mm
		872981 SOX2_MOUSE (1-317): 2.25e-70: 223: 94.67		CUL4A_MOUSE (1-759): 0: 972: 95.13
+	Hs
		872308 SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00		CUL4B_HUMAN (10-759): 0: 922: 82.31
+	Mm
		58987 SOX2_MOUSE (1-317): 2.25e-70: 223: 94.67		CUL4B_MOUSE (10-759): 0: 922: 82.18
+	Hs
		873083 SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57		CUL4A_HUMAN (1-759): 0: 958: 100.00
+	Hs
		1065182 SSRP1_HUMAN (22-202): 4.59e-31: 124: 15.93		CUL4A_HUMAN (1-759): 0: 958: 100.00
+	Hs
		873084 SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57		CUL4B_HUMAN (10-759): 0: 922: 82.31
+	Hs
		833578 SOX3_HUMAN (1-317): 1.33e-42: 154: 46.15		CUL3_HUMAN (32-759): 0: 810: 38.23
+	Hs
		873082 SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57		CUL3_HUMAN (32-759): 0: 810: 38.23
+	Hs
		1114070 CIC_HUMAN (3-272): 4.72e-28: 116: 19.08		CUL3_HUMAN (32-759): 0: 810: 38.23
+	Hs
		873080 SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57		CUL1_HUMAN (59-759): 0: 740: 30.55
+	Hs
		873081 SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57		CUL2_HUMAN (51-759): 0: 706: 27.26
+	Dm
		1303218 PANG2_DROME (18-276): 9.31e-32: 127: 13.41		Q9V9R2_DROME (51-759): 0: 654: 24.44
+	Hs
		873115 SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57		CUL5_HUMAN (59-759): 0: 586: 25.07
+	Hs
		325215 SOX30_HUMAN (1-286): 3.69e-29: 119: 20.00		CUL5_HUMAN (59-759): 0: 586: 25.07