Protein: SOX9
Transcription factor SOX-9

Gene: SOX9
Organism: Homo sapiens
Interactions: 93
UniProt ID: P48436

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873117

FBXW7
F-box/WD repeat-containing protein 7

4

20

Small-scale

0.689

High

873076

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.676

High

873064

SOX9
Transcription factor SOX-9

1

17

Small-scale

0.647

High

873100

PB1
Protein polybromo-1

1

20

High-throughput

0.618

High

873120

CIC
Protein capicua homolog

1

20

High-throughput

0.618

High

873085

RUNX2
Runt-related transcription factor 2

2

9

Small-scale

0.602

High

873065

GSK3B
Glycogen synthase kinase-3 beta

2

12

Small-scale

0.595

High

873070

UBC9
SUMO-conjugating enzyme UBC9

2

11

Small-scale

0.595

High

873126

ZRAN1
Ubiquitin thioesterase ZRANB1

2

14

Small-scale

0.584

High

282171

MAF
Transcription factor Maf

1

1

Small-scale

0.573

High

873079

STF1
Steroidogenic factor 1

1

20

Small-scale

0.573

High

873116

MED12
Mediator of RNA polymerase II transcription subunit 12

1

20

Small-scale

0.573

High

473853

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

873088

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.561

High

873089

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

15

Small-scale

0.561

High

873114

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

15

Small-scale

0.561

High

873068

RCAN1
Calcipressin-1

1

1

High-throughput

0.541

High

605595

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

6

Small-scale

0.527

High

873078

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.515

High

775810

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.501

High

873072

ELF3
ETS-related transcription factor Elf-3

1

20

Small-scale

0.501

High

873106

CR3L4
Cyclic AMP-responsive element-binding protein 3-like protein 4

1

13

Small-scale

0.501

High

873129

VATH
V-type proton ATPase subunit H

1

1

High-throughput

0.494

High

138979

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

142891

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

154648

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161432

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174325

ZN609
Zinc finger protein 609

1

20

High-throughput

0.479

High

194526

KDM6A
Lysine-specific demethylase 6A

1

15

High-throughput

0.479

High

259605

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

334527

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

16

Small-scale

0.479

High

615497

NELFE
Negative elongation factor E

1

7

High-throughput

0.479

High

685121

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

814765

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.479

High

873066

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

873067

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

High-throughput

0.479

High

873071

H31
Histone H3.1

1

20

High-throughput

0.479

High

873073

SMAD3
Mothers against decapentaplegic homolog 3

1

17

Small-scale

0.479

High

873074

H33
Histone H3.3

1

20

High-throughput

0.479

High

873075

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

873077

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.479

High

873080

CUL1
Cullin-1

1

17

Small-scale

0.479

High

873081

CUL2
Cullin-2

1

17

Small-scale

0.479

High

873082

CUL3
Cullin-3

1

17

Small-scale

0.479

High

873083

CUL4A
Cullin-4A

1

17

Small-scale

0.479

High

873084

CUL4B
Cullin-4B

1

17

Small-scale

0.479

High

873086

KEAP1
Kelch-like ECH-associated protein 1

1

9

Small-scale

0.479

High

873087

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.479

High

873090

SMAD2
Mothers against decapentaplegic homolog 2

1

17

Small-scale

0.479

High

873091

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

873093

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

873094

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

20

High-throughput

0.479

High

873096

UBN2
Ubinuclein-2

1

20

High-throughput

0.479

High

873097

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

873098

SCX
Basic helix-loop-helix transcription factor scleraxis

1

12

Small-scale

0.479

High

873099

MAVS
Mitochondrial antiviral-signaling protein

1

12

Small-scale

0.479

High

873101

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

873102

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

873103

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

873104

KDM2B
Lysine-specific demethylase 2B

1

6

High-throughput

0.479

High

873105

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

High-throughput

0.479

High

873107

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

873108

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

9

High-throughput

0.479

High

873109

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

873110

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

873111

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

873112

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

873113

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

17

High-throughput

0.479

High

873115

CUL5
Cullin-5

1

17

Small-scale

0.479

High

873118

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

10

High-throughput

0.479

High

873119

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

873121

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

873122

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

873124

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

High-throughput

0.479

High

873128

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

873130

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

873131

UBP18
Ubl carboxyl-terminal hydrolase 18

1

17

Small-scale

0.479

High

873132

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.479

High

873133

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.479

High

873134

ZN281
Zinc finger protein 281

1

16

High-throughput

0.479

High

873135

FBX7
F-box only protein 7

1

3

Small-scale

0.479

High

873136

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

873137

NCOA3
Nuclear receptor coactivator 3

1

20

High-throughput

0.479

High

873069

RD23A
UV excision repair protein RAD23 homolog A

1

4

High-throughput

0.445

High

155556

NEMP1
Nuclear envelope integral membrane protein 1

1

1

High-throughput

0.437

High

515777

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

7

High-throughput

0.437

High

873095

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

873123

KLHL1
Kelch-like protein 1

1

6

Small-scale

0.437

High

873125

KLH13
Kelch-like protein 13

1

9

Small-scale

0.437

High

873127

KLHL3
Kelch-like protein 3

1

6

Small-scale

0.437

High

142298

PEX7
Peroxisomal targeting signal 2 receptor

1

20

High-throughput

0.407

High

873092

WLS
Protein wntless homolog

2

0

Small-scale

0.304

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025