HitPredict

Interactor 1: EPHA5 (P54756)
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Gene: EPHA5

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0030424 - axon GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1037 Hs			1 1332
+	Hs
		1072547 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		872502 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324761 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		1072625 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		665680 EPHB2_HUMAN (60-1034): 0: 1209: 56.80		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324762 EPHA4_HUMAN (33-1035): 0: 1223: 62.04		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324809 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324742 EPHB2_HUMAN (60-1034): 0: 1209: 56.80		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324738 EPHA1_HUMAN (47-1028): 0: 995: 41.78		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		872510 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		433891 LYN_HUMAN (659-933): 1.73e-65: 231: 43.68		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		324720 IGF1R_HUMAN (294-1017): 7.97e-145: 469: 23.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		1072635 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		434067 LYN_HUMAN (659-933): 1.73e-65: 231: 43.68		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324719 LYN_HUMAN (659-933): 1.73e-65: 231: 43.68		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		674399 UFO_HUMAN (290-1017): 4.06e-147: 463: 21.89		M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26
+	Hs
		987310 TYRO3_HUMAN (293-975): 8.48e-147: 462: 21.19		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		433850 LYN_HUMAN (659-933): 1.73e-65: 231: 43.68		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		433949 LYN_HUMAN (659-933): 1.73e-65: 231: 43.68		MARK4_HUMAN (16-739): 9.59e-118: 387: 17.15
+	Hs
		442897 HCK_HUMAN (653-933): 1.21e-65: 232: 42.76		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60