HitPredict

Interactor 1: EPHB2 (P54763)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16298995
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Mm			1 217
+	Hs
		665574 EPHB2_HUMAN (20-985): 0: 1256: 99.59		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		872610 EPHB1_HUMAN (19-980): 0: 1225: 74.01		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		924590 EPHA7_HUMAN (6-986): 0: 1174: 57.13		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		872422 EPHA5_HUMAN (6-978): 0: 1168: 55.98		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		872619 EPHB2_MOUSE (1-986): 0: 1264: 100.00		ABL2_MOUSE (4-139): 1.55e-20: 91.3: 33.33
+	Hs
		337360 EPHB2_HUMAN (20-985): 0: 1256: 99.59		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		665558 EPHB2_HUMAN (20-985): 0: 1256: 99.59		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Mm
		403425 EPHB2_MOUSE (1-986): 0: 1264: 100.00		SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24
+	Hs
		433265 EPHB2_HUMAN (20-985): 0: 1256: 99.59		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		557644 EPHB1_HUMAN (19-980): 0: 1225: 74.01		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		665608 EPHB2_HUMAN (20-985): 0: 1256: 99.59		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Hs
		522803 EPHB2_HUMAN (20-985): 0: 1256: 99.59		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		789068 EPHA7_HUMAN (6-986): 0: 1174: 57.13		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Mm
		337625 EPHA4_MOUSE (6-986): 0: 1170: 58.09		ABL1_MOUSE (4-139): 4.43e-22: 95.5: 35.46
+	Hs
		557643 EPHA5_HUMAN (6-978): 0: 1168: 55.98		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Mm
		763386 EPHA4_MOUSE (6-986): 0: 1170: 58.09		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		412104 EPHA5_HUMAN (6-978): 0: 1168: 55.98		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		412105 EPHA4_HUMAN (6-986): 0: 1166: 58.19		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		433772 EPHA7_HUMAN (6-986): 0: 1174: 57.13		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		433662 EPHA4_HUMAN (6-986): 0: 1166: 58.19		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39