HitPredict

Interactor 1: EIF3B (P55884)
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)
Gene: EIF3B

Interactor 2: RPTOR (Q8N122)
Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Gene: RPTOR

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	16286006, 21045808
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	eIF2A~WD40
Common GO terms	GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 814 Hs			1 1335
+	Hs
		879196 EIF3B_HUMAN (1-814): 0: 830: 100.00		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Sc
		410198 EIF3B_YEAST (139-790): 1.9e-118: 377: 29.36		PRP46_YEAST (1076-1328): 1.96e-14: 79.5: 20.78
+	Hs
		245633 TBL1X_HUMAN (408-730): 4.48e-54: 198: 11.02		TBL1R_HUMAN (1059-1334): 3.26e-59: 215: 12.50
+	Hs
		245546 TBL1X_HUMAN (408-730): 4.48e-54: 198: 11.02		TBL1X_HUMAN (1059-1334): 1.32e-55: 206: 14.24
+	Hs
		245630 TBL1X_HUMAN (408-730): 4.48e-54: 198: 11.02		TBL1Y_HUMAN (1059-1334): 2.8e-54: 200: 13.54
+	Hs
		1309163 TBL1R_HUMAN (408-730): 1.7e-53: 195: 11.90		TBL1Y_HUMAN (1059-1334): 2.8e-54: 200: 13.54
+	Hs
		903418 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		903551 NLE1_HUMAN (507-723): 2.49e-34: 139: 17.03		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Hs
		903077 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Dm
		1358845 WDS_DROME (553-729): 2.22e-33: 134: 12.09		WDS_DROME (1109-1334): 2.48e-63: 221: 18.50
+	Hs
		792949 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		LIS1_HUMAN (1101-1334): 4.69e-55: 199: 15.69
+	Dm
		1358859 WDS_DROME (553-729): 2.22e-33: 134: 12.09		FBXW7_DROME (674-1289): 8.13e-51: 199: 10.65
+	Hs
		903349 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		WDR5B_HUMAN (1200-1334): 8.32e-30: 123: 11.77
+	Hs
		903154 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		TLE3_HUMAN (1165-1335): 2.38e-23: 109: 13.07
+	Sp
		999842 TUP12_SCHPO (233-498): 5.52e-30: 128: 17.73		TUP11_SCHPO (1191-1334): 3.17e-26: 117: 13.91
+	Hs
		903428 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		SNR40_HUMAN (1246-1335): 6.58e-16: 82.9: 17.58
+	Hs
		725410 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		COPB2_HUMAN (1197-1333): 5.9e-15: 82.2: 15.83
+	Hs
		863397 WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71		COPA_HUMAN (1009-1182): 1.34e-10: 68.3: 17.62