HitPredict

Interactor 1: WNT3A (P56704)
Protein Wnt-3a
Gene: WNT3A

Interactor 2: WLS (Q5T9L3)
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
Gene: WLS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.850

Property	Details
Experiments	33961781, 24768165, 22784633
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, fluorescence microscopy
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MIG-14_Wnt-bd~wnt
Common GO terms	GO:0005886 - plasma membrane GO:0030666 - endocytic vesicle membrane GO:0031901 - early endosome membrane GO:0070062 - extracellular exosome GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 541
+	Mm
		568285 WNT3_MOUSE (12-352): 8.14e-180: 503: 85.92		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		1135438 WNT5B_HUMAN (12-352): 7.63e-153: 435: 45.35		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		611175 WNT5A_MOUSE (10-352): 7.41e-152: 434: 43.86		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		782089 WNT5A_HUMAN (7-352): 2.86e-152: 435: 43.49		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		382254 WNT1_MOUSE (23-351): 4.85e-148: 424: 45.10		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		881881 WNT4_HUMAN (18-352): 6.32e-149: 425: 47.93		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		384072 WNT1_HUMAN (23-351): 3.86e-148: 424: 45.10		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		881899 WNT7B_HUMAN (26-352): 1.59e-148: 424: 45.29		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		451998 WNT2_HUMAN (21-352): 1.19e-147: 422: 43.16		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		135861 WNT7A_HUMAN (11-352): 1.44e-146: 419: 42.15		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135451 WNT16_HUMAN (22-352): 2.82e-132: 383: 41.91		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135437 WNT8A_HUMAN (57-351): 4.17e-124: 362: 39.47		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		158076 WNT9B_HUMAN (25-352): 2.19e-121: 355: 32.23		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		158068 WNT9A_HUMAN (42-352): 1.68e-116: 343: 33.02		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135420 WNT8B_HUMAN (57-351): 1.99e-111: 330: 38.94		WLS_HUMAN (1-541): 0: 811: 100.00
+	Dm
		658764 WNT2_DROME (37-352): 1.36e-125: 366: 46.51		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		776060 WNT4_DROME (32-352): 1.87e-107: 326: 31.90		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		1279554 Q9VM25_DROME (42-335): 1.15e-96: 297: 31.46		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		658776 WNT5_DROME (28-178): 3.99e-49: 178: 37.42		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		452324 WNTG_DROME (255-351): 3.27e-39: 146: 46.39		WLS_DROME (1-535): 0: 642: 40.82