HitPredict

Interactor 1: GBG2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Gene: GNG2

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 33961781, 10339615, 19168127, 9789084, 15889144, 19376773, 16301321, 35271311, 15782186, 12782285, 12606627, 18611381, 23739333
Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer, molecular sieving, ion exchange chromatography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains G-gamma~WD40
Common GO terms GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007191 - adenylate cyclase-activating dopamine receptor signaling pathway
GO:0016020 - membrane
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 71
Hs

1 340
+ Hs
+ Hs
+ Bt
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024