HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	34133714
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 484 Hs			1 282
+	Hs
		889645 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF8_HUMAN (1-282): 5.36e-41: 144: 100.00
+	Hs
		889799 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		SRSF8_HUMAN (1-282): 5.36e-41: 144: 100.00
+	Hs
		889561 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		667816 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		550181 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		550125 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		889720 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Dm
		889876 DOA_DROME (19-481): 2.38e-114: 357: 46.15		Q9V3T8_DROME (5-181): 7.1e-31: 115: 50.83
+	Hs
		889723 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		PABP4_HUMAN (2-103): 3.84e-21: 94.8: 19.61
+	Hs
		550182 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		1090221 DYR1A_HUMAN (40-478): 6.14e-103: 326: 25.15		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		1101947 DYR1A_HUMAN (40-478): 6.14e-103: 326: 25.15		PABP4_HUMAN (2-103): 3.84e-21: 94.8: 19.61
+	Hs
		550275 DYR1A_HUMAN (40-478): 6.14e-103: 326: 25.15		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		1115639 DYR1A_HUMAN (40-478): 6.14e-103: 326: 25.15		CIRBP_HUMAN (16-160): 2.3e-19: 85: 33.79