HitPredict

Interactor 1: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Interactor 2: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 403 Hs			1 1374
+	Hs
		1167717 TPTE2_HUMAN (1-347): 4.78e-106: 324: 34.72		LMTK1_HUMAN (1-1374): 0: 976: 100.00
+	Hs
		1168441 CC14A_HUMAN (17-176): 1.42e-36: 142: 19.16		LMTK1_HUMAN (1-1374): 0: 976: 100.00
+	Hs
		56538 PTPC1_HUMAN (26-161): 2.55e-25: 110: 23.38		LMTK1_HUMAN (1-1374): 0: 976: 100.00
+	Hs
		1167721 TPTE2_HUMAN (1-347): 4.78e-106: 324: 34.72		LMTK2_HUMAN (9-1366): 0: 690: 29.74
+	Hs
		872609 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		EPHB1_HUMAN (6-505): 2.12e-123: 410: 19.80
+	Hs
		161650 GAK_HUMAN (22-402): 1.74e-116: 370: 23.39		ACK1_HUMAN (54-854): 2.25e-146: 474: 21.51
+	Hs
		1219452 CC14A_HUMAN (17-176): 1.42e-36: 142: 19.16		LMTK2_HUMAN (9-1366): 0: 690: 29.74
+	Hs
		56542 PTPC1_HUMAN (26-161): 2.55e-25: 110: 23.38		LMTK2_HUMAN (9-1366): 0: 690: 29.74
+	Hs
		508060 TENS2_HUMAN (16-402): 1.75e-109: 352: 24.88		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		665386 TPTE_HUMAN (1-347): 1.17e-102: 316: 33.61		EPHA3_HUMAN (12-404): 1.11e-104: 358: 23.74
+	Hs
		433843 TPTE2_HUMAN (1-347): 4.78e-106: 324: 34.72		LYN_HUMAN (109-410): 9.62e-106: 347: 24.75
+	Hs
		890645 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90
+	Rn
		94036 F1LN91_RAT (17-402): 1.03e-110: 356: 26.01		INSR_RAT (111-395): 8.57e-39: 160: 35.25
+	Hs
		161607 GAK_HUMAN (22-402): 1.74e-116: 370: 23.39		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		161738 GAK_HUMAN (22-402): 1.74e-116: 370: 23.39		ALK_HUMAN (109-386): 2.69e-32: 139: 32.99
+	Hs
		1031142 TPTE2_HUMAN (1-347): 4.78e-106: 324: 34.72		PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90
+	Ce
		106533 PTEN_CAEEL (1-402): 6.39e-108: 341: 26.53		INSR_CAEEL (129-410): 1.24e-31: 137: 32.22
+	Hs
		879798 TPTE_HUMAN (1-347): 1.17e-102: 316: 33.61		PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90
+	Hs
		384574 TPTE_HUMAN (1-347): 1.17e-102: 316: 33.61		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		1031180 CC14A_HUMAN (17-176): 1.42e-36: 142: 19.16		PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90