HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0050811 - GABA receptor binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 1308
+	Hs
		601867 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383718 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		601995 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383970 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		338214 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338975 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		EGFR_HUMAN (20-1286): 0: 1039: 48.70