Protein: MYPT1
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)

Gene: MYPT1, PPP1R12A
Organism: Homo sapiens
Interactions: 243
UniProt ID: O14974

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0001725 - stress fiber
GO:0004857 - enzyme inhibitor activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

171202

CDK8
Cyclin-dependent kinase 8

3

9

High-throughput

0.861

High

171206

PLK1
Serine/threonine-protein kinase PLK1

2

11

Small-scale

0.819

High

171323

NUAK2
NUAK family SNF1-like kinase 2

4

6

High-throughput

0.805

High

171128

NUAK1
NUAK family SNF1-like kinase 1

2

6

Small-scale

0.789

High

171192

CCNF
Cyclin-F

2

6

High-throughput

0.754

High

171145

CHK2
Serine/threonine-protein kinase Chk2

1

7

Small-scale

0.747

High

171217

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

5

20

Small-scale

0.727

High

171143

LATS1
Serine/threonine-protein kinase LATS1

1

10

Small-scale

0.724

High

171126

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

18

High-throughput

0.715

High

171318

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

16

High-throughput

0.715

High

171319

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

18

High-throughput

0.715

High

171341

RAI14
Ankycorbin

1

16

High-throughput

0.715

High

163011

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.708

High

171177

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.691

High

171196

CRK
Adapter molecule crk

1

11

High-throughput

0.691

High

171199

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.691

High

171200

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.691

High

171211

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

171244

SRC8
Src substrate cortactin

1

19

High-throughput

0.691

High

171270

TLK2
Serine/threonine-protein kinase tousled-like 2

1

11

High-throughput

0.691

High

171277

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

20

High-throughput

0.691

High

171350

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

5

High-throughput

0.691

High

171122

DAPK3
Death-associated protein kinase 3

1

5

Small-scale

0.690

High

171232

DMPK
Myotonin-protein kinase

2

4

Small-scale

0.669

High

171133

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

5

High-throughput

0.667

High

171316

PHF7
E3 ubiquitin-protein ligase PHF7

3

1

High-throughput

0.667

High

171335

ANLN
Anillin

3

4

High-throughput

0.656

High

171215

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

171230

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

171157

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.647

High

171242

KGP1
cGMP-dependent protein kinase 1

1

9

Small-scale

0.647

High

171343

ATX10
Ataxin-10

3

0

Small-scale

0.636

High

171120

ZN263
Zinc finger protein 263

2

20

High-throughput

0.628

High

171136

TULP3
Tubby-related protein 3

2

3

High-throughput

0.628

High

171153

PAI2
Plasminogen activator inhibitor 2

2

3

High-throughput

0.628

High

171171

JUNB
Transcription factor JunB

2

7

High-throughput

0.628

High

171268

3BP5L
SH3 domain-binding protein 5-like

2

4

High-throughput

0.628

High

171291

ANR49
Ankyrin repeat domain-containing protein 49

1

16

High-throughput

0.618

High

171348

ANR50
Ankyrin repeat domain-containing protein 50

1

15

High-throughput

0.618

High

156696

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.618

High

171119

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

18

High-throughput

0.618

High

171125

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.618

High

171138

RECQ4
ATP-dependent DNA helicase Q4

1

9

High-throughput

0.618

High

171139

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.618

High

171150

P53
Cellular tumor antigen p53

1

6

Small-scale

0.618

High

171156

FYN
Tyrosine-protein kinase Fyn

1

10

High-throughput

0.618

High

171163

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

8

High-throughput

0.618

High

171169

VAV
Proto-oncogene vav

1

4

High-throughput

0.618

High

171185

CTNB1
Catenin beta-1

1

8

High-throughput

0.618

High

171195

RECQ1
ATP-dependent DNA helicase Q1

1

7

High-throughput

0.618

High

171203

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.618

High

171205

NEK2
Serine/threonine-protein kinase Nek2

1

7

Small-scale

0.618

High

171219

RAN
GTP-binding nuclear protein Ran

1

14

Small-scale

0.618

High

171228

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.618

High

171229

TF65
Transcription factor p65

1

6

High-throughput

0.618

High

171239

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.618

High

171241

DX39B
Spliceosome RNA helicase DDX39B

1

4

High-throughput

0.618

High

171246

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.618

High

171248

MYLK
Myosin light chain kinase, smooth muscle

1

11

High-throughput

0.618

High

171252

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

Small-scale

0.618

High

171266

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

171267

PAXI1
PAX-interacting protein 1

1

5

High-throughput

0.618

High

171294

TRIB2
Tribbles homolog 2

1

3

Small-scale

0.618

High

171304

AURKB
Aurora kinase B

1

3

Small-scale

0.618

High

171312

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

1

High-throughput

0.618

High

171317

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.618

High

171326

SIK2
Serine/threonine-protein kinase SIK2

1

4

Small-scale

0.618

High

171331

ECT2
Protein ECT2

1

10

High-throughput

0.618

High

171344

HDAC6
Protein deacetylase HDAC6

1

8

High-throughput

0.618

High

171352

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

3

High-throughput

0.618

High

171146

FOS
Protein c-Fos

2

15

High-throughput

0.611

High

171249

DREB
Drebrin

2

7

High-throughput

0.611

High

171333

SP110
Sp110 nuclear body protein

2

12

High-throughput

0.611

High

171165

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

171168

ENPL
Endoplasmin

2

8

High-throughput

0.601

High

171170

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

171179

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.584

High

171187

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

171191

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

20

Small-scale

0.584

High

171218

1433E
14-3-3 protein epsilon

2

3

Small-scale

0.584

High

171129

KDM1A
Lysine-specific histone demethylase 1A

1

4

Small-scale

0.578

High

171132

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.575

High

171214

RHOA
Transforming protein RhoA

1

20

Small-scale

0.575

High

171222

GRB2
Growth factor receptor-bound protein 2

1

13

High-throughput

0.575

High

171234

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

9

High-throughput

0.575

High

171311

ZBT18
Zinc finger and BTB domain-containing protein 18

1

20

High-throughput

0.575

High

171243

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

15

Small-scale

0.573

High

171148

ESR1
Estrogen receptor

2

15

High-throughput

0.571

High

171216

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

20

High-throughput

0.571

High

171223

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.571

High

171255

SYDE2
Rho GTPase-activating protein SYDE2

2

11

High-throughput

0.571

High

171258

FTM
Protein fantom

2

14

High-throughput

0.571

High

171264

MPRIP
Myosin phosphatase Rho-interacting protein

2

17

Small-scale

0.571

High

171327

TARA
TRIO and F-actin-binding protein

1

17

High-throughput

0.554

High

171161

CALM3
Calmodulin-3

1

0

High-throughput

0.546

High

123504

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.536

High

161658

TRDMT
tRNA

1

1

High-throughput

0.536

High

171124

ACTN4
Alpha-actinin-4

1

14

High-throughput

0.536

High

171131

CC14B
Dual specificity protein phosphatase CDC14B

1

13

High-throughput

0.536

High

171134

TP4A3
Protein tyrosine phosphatase type IVA 3

1

12

High-throughput

0.536

High

171135

SH3L1
Adapter SH3BGRL

1

2

High-throughput

0.536

High

171137

TRPM2
Transient receptor potential cation channel subfamily M member 2

1

1

High-throughput

0.536

High

171142

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

171175

FLNA
Filamin-A

1

16

High-throughput

0.536

High

171183

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

171188

MYH9
Myosin-9

1

5

High-throughput

0.536

High

171190

AHR
Aryl hydrocarbon receptor

1

2

High-throughput

0.536

High

171198

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.536

High

171207

CLH2
Clathrin heavy chain 2

1

1

High-throughput

0.536

High

171208

HAP1
Huntingtin-associated protein 1

1

6

High-throughput

0.536

High

171209

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

171212

ARP2
Actin-related protein 2

1

7

High-throughput

0.536

High

171221

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

3

High-throughput

0.536

High

171231

CALD1
Caldesmon

1

20

High-throughput

0.536

High

171235

MALL
MAL-like protein

1

1

High-throughput

0.536

High

171238

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.536

High

171247

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

171260

CYTSA
Cytospin-A

1

14

High-throughput

0.536

High

171269

MILR1
Allergin-1

1

8

High-throughput

0.536

High

171274

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.536

High

171275

SYNPO
Synaptopodin

1

10

High-throughput

0.536

High

171276

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.536

High

171279

POC1A
POC1 centriolar protein homolog A

1

6

High-throughput

0.536

High

171282

BBS1
BBSome complex member BBS1

1

1

High-throughput

0.536

High

171292

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

171293

JPH3
Junctophilin-3

1

3

High-throughput

0.536

High

171296

MY18A
Unconventional myosin-XVIIIa

1

11

High-throughput

0.536

High

171297

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

7

High-throughput

0.536

High

171298

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

171305

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

171330

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.536

High

171336

MYO5C
Unconventional myosin-Vc

1

3

High-throughput

0.536

High

171345

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

2

High-throughput

0.536

High

171353

WIF1
Wnt inhibitory factor 1

1

13

High-throughput

0.536

High

171121

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

0

Small-scale

0.529

High

171151

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.515

High

171167

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

171172

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

171189

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.513

High

171194

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

High-throughput

0.513

High

171224

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

171226

CXCL6
C-X-C motif chemokine 6

1

0

High-throughput

0.513

High

171286

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

171334

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

171337

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

171354

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

171287

SETD7
Histone-lysine N-methyltransferase SETD7

1

3

Small-scale

0.501

High

171301

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.501

High

171263

CORO6
Coronin-6

1

9

High-throughput

0.489

High

171306

IMP1L
Mitochondrial inner membrane protease subunit 1

1

5

High-throughput

0.489

High

171309

IMP2L
Mitochondrial inner membrane protease subunit 2

1

5

High-throughput

0.489

High

171313

SOST
Sclerostin

1

3

High-throughput

0.489

High

171332

MAGF1
Melanoma-associated antigen F1

1

7

High-throughput

0.489

High

171250

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

Small-scale

0.480

High

171123

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

171127

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

171140

FMNL1
Formin-like protein 1

1

3

Small-scale

0.479

High

171141

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

171147

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

171149

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

171154

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.479

High

171158

ENOA
Alpha-enolase

1

4

High-throughput

0.479

High

171160

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

171164

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

171166

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

171173

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

High-throughput

0.479

High

171174

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

171178

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

171180

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.479

High

171181

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

171182

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

171193

CASR
Extracellular calcium-sensing receptor

1

2

Small-scale

0.479

High

171197

YAP1
Transcriptional coactivator YAP1

1

14

High-throughput

0.479

High

171201

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

171204

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

171210

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.479

High

171220

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

171227

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

High-throughput

0.479

High

171233

AHNK
Neuroblast differentiation-associated protein AHNAK

1

12

High-throughput

0.479

High

171245

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

171251

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

5

High-throughput

0.479

High

171257

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.479

High

171259

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

171262

RHGBA
Rho GTPase-activating protein 11A

1

9

High-throughput

0.479

High

171265

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

9

High-throughput

0.479

High

171271

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

171272

ARHGP
Rho guanine nucleotide exchange factor 25

1

10

High-throughput

0.479

High

171273

RHG24
Rho GTPase-activating protein 24

1

10

High-throughput

0.479

High

171281

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

171284

RBCC1
RB1-inducible coiled-coil protein 1

1

20

Small-scale

0.479

High

171288

HDAC7
Histone deacetylase 7

1

8

Small-scale

0.479

High

171289

RN138
E3 ubiquitin-protein ligase RNF138

1

7

High-throughput

0.479

High

171295

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

171302

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

171322

WWTR1
WW domain-containing transcription regulator protein 1

1

12

High-throughput

0.479

High

171324

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

171325

RNF38
E3 ubiquitin-protein ligase RNF38

1

3

Small-scale

0.479

High

171328

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

171329

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

171338

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

High-throughput

0.479

High

171339

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

17

Small-scale

0.479

High

171340

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

171346

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

171347

SEPT9
Septin-9

1

3

Small-scale

0.479

High

171349

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.479

High

171130

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

171176

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

171213

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

171225

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

High-throughput

0.458

High

171240

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

171283

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

171285

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

171290

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

171300

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.458

High

171321

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

171342

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

171155

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

171162

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.445

High

171184

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.445

High

171186

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

171261

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.445

High

171280

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.445

High

171299

CSN5
COP9 signalosome complex subunit 5

1

6

Small-scale

0.445

High

171307

CEP63
Centrosomal protein of 63 kDa

1

12

High-throughput

0.445

High

171308

S22AC
Solute carrier family 22 member 12

1

3

High-throughput

0.445

High

171320

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

104848

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

171152

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

171159

NFM
Neurofilament medium polypeptide

1

14

High-throughput

0.437

High

171278

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

171314

OVOL2
Transcription factor Ovo-like 2

1

20

Small-scale

0.437

High

171237

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

171310

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.426

High

171253

MF14B
Hippocampus abundant transcript-like protein 1

1

3

High-throughput

0.407

High

171254

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

143954

EST2
Cocaine esterase

1

0

High-throughput

0.279

Low

171144

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

171236

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

171303

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

171315

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

171351

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

171256

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025