Protein: ASPP2
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)

Gene: ASPP2, TP53BP2
Organism: Homo sapiens
Interactions: 237
UniProt ID: Q13625

Gene Ontology (top 5):
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

413797

P53
Cellular tumor antigen p53

11

16

Small-scale

0.979

High

212770

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

3

7

High-throughput

0.861

High

522090

BCL2
Apoptosis regulator Bcl-2

2

3

Small-scale

0.839

High

1060164

B2CL1
Bcl-2-like protein 1

2

3

Small-scale

0.826

High

1045266

TF65
Transcription factor p65

2

15

Small-scale

0.825

High

1115511

ASPP2
Apoptosis-stimulating of p53 protein 2

2

20

Small-scale

0.820

High

1115588

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

13

Small-scale

0.819

High

943761

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

12

High-throughput

0.817

High

1115630

BAIP2
BAR/IMD domain-containing adapter protein 2

2

15

High-throughput

0.817

High

1115575

B2CL2
Bcl-2-like protein 2

2

3

Small-scale

0.799

High

132021

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

13

High-throughput

0.789

High

764733

CTNB1
Catenin beta-1

2

14

Small-scale

0.789

High

786595

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

14

20

Small-scale

0.763

High

967717

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

13

20

Small-scale

0.762

High

862111

YAP1
Transcriptional coactivator YAP1

12

20

Small-scale

0.760

High

855616

CRK
Adapter molecule crk

2

16

High-throughput

0.757

High

981484

RAN
GTP-binding nuclear protein Ran

1

13

Small-scale

0.757

High

1107695

SQSTM
Sequestosome-1

2

15

High-throughput

0.754

High

1115632

NINL
Ninein-like protein

2

16

High-throughput

0.754

High

1115565

RASF8
Ras association domain-containing protein 8

7

11

High-throughput

0.748

High

987619

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.740

High

968289

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

5

20

High-throughput

0.728

High

1049271

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

861599

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

13

Small-scale

0.715

High

353774

APCL
Adenomatous polyposis coli protein 2

1

18

Small-scale

0.713

High

1115567

PARD3
Partitioning defective 3 homolog

5

19

Small-scale

0.711

High

1039102

RASF7
Ras association domain-containing protein 7

4

12

High-throughput

0.699

High

729815

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.699

High

966291

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

1050416

UBE3A
Ubiquitin-protein ligase E3A

1

20

High-throughput

0.699

High

1087001

KIF5A
Kinesin heavy chain isoform 5A

1

4

High-throughput

0.698

High

990198

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.694

High

1115603

PAR6B
Partitioning defective 6 homolog beta

1

2

High-throughput

0.691

High

1115616

PAR6A
Partitioning defective 6 homolog alpha

1

4

High-throughput

0.691

High

971500

1433E
14-3-3 protein epsilon

3

8

High-throughput

0.671

High

1115559

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

3

7

High-throughput

0.670

High

163929

NDC80
Kinetochore protein NDC80 homolog

3

16

High-throughput

0.669

High

1115549

HOME1
Homer protein homolog 1

3

11

High-throughput

0.667

High

1115592

FRMD6
FERM domain-containing protein 6

3

20

High-throughput

0.667

High

690986

1433T
14-3-3 protein theta

3

20

High-throughput

0.662

High

965446

LMO4
LIM domain transcription factor LMO4

1

20

High-throughput

0.662

High

919951

PLK1
Serine/threonine-protein kinase PLK1

1

10

High-throughput

0.656

High

1103686

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

9

High-throughput

0.656

High

186752

P73
Tumor protein p73

1

16

Small-scale

0.647

High

507944

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.647

High

1115609

P63
Tumor protein 63

1

16

Small-scale

0.647

High

1115585

SGF29
SAGA-associated factor 29

3

0

High-throughput

0.638

High

821100

TXLNA
Alpha-taxilin

2

13

High-throughput

0.633

High

1115526

PKHN1
Pleckstrin homology domain-containing family N member 1

2

5

High-throughput

0.633

High

1115552

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

11

High-throughput

0.633

High

1115563

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

1

High-throughput

0.633

High

1115569

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

3

High-throughput

0.633

High

1115584

OTUB2
Ubiquitin thioesterase OTUB2

2

1

High-throughput

0.633

High

1115631

ADIP
Afadin- and alpha-actinin-binding protein

2

2

High-throughput

0.631

High

1115629

PRP19
Pre-mRNA-processing factor 19

2

12

High-throughput

0.628

High

1115529

CCD92
Coiled-coil domain-containing protein 92

2

1

High-throughput

0.628

High

325396

DIRA1
GTP-binding protein Di-Ras1

1

10

High-throughput

0.621

High

364135

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

1

High-throughput

0.621

High

684232

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.621

High

714616

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.621

High

933836

GEM
GTP-binding protein GEM

1

6

High-throughput

0.621

High

1115514

ARHG6
Rho guanine nucleotide exchange factor 6

1

11

High-throughput

0.621

High

1115517

RBP1
RalA-binding protein 1

1

13

High-throughput

0.621

High

1115544

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

11

High-throughput

0.621

High

1115568

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

14

High-throughput

0.621

High

1115578

LHX4
LIM/homeobox protein Lhx4

1

16

High-throughput

0.621

High

1115580

SH3K1
SH3 domain-containing kinase-binding protein 1

1

17

High-throughput

0.621

High

1115621

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

3

High-throughput

0.621

High

1115627

DP13A
DCC-interacting protein 13-alpha

1

3

High-throughput

0.621

High

349070

LATS1
Serine/threonine-protein kinase LATS1

1

18

High-throughput

0.618

High

541474

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

830701

CCNF
Cyclin-F

1

6

High-throughput

0.618

High

835667

KPCI
Protein kinase C iota type

1

12

Small-scale

0.618

High

891156

GSK3A
Glycogen synthase kinase-3 alpha

1

17

High-throughput

0.618

High

891527

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.618

High

1058828

ZO1
Tight junction protein 1

1

15

High-throughput

0.618

High

1115520

ZYX
Zyxin

1

14

High-throughput

0.618

High

1115535

FTM
Protein fantom

1

20

High-throughput

0.618

High

1115550

MIB1
E3 ubiquitin-protein ligase MIB1

1

17

High-throughput

0.618

High

1115561

CE120
Centrosomal protein of 120 kDa

1

17

High-throughput

0.618

High

1115590

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

19

High-throughput

0.618

High

1115611

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1115618

LATS2
Serine/threonine-protein kinase LATS2

1

16

High-throughput

0.618

High

1115625

ZO2
Tight junction protein 2

1

8

High-throughput

0.618

High

66497

RASFA
Ras association domain-containing protein 10

2

4

High-throughput

0.614

High

1115619

TB22B
TBC1 domain family member 22B

3

3

High-throughput

0.606

High

556067

CADH1
Cadherin-1

2

6

Small-scale

0.594

High

246590

KDM1A
Lysine-specific histone demethylase 1A

2

8

High-throughput

0.586

High

1115516

PCM1
Pericentriolar material 1 protein

2

1

High-throughput

0.584

High

1115527

AMOT
Angiomotin

2

20

High-throughput

0.584

High

1115558

NIN
Ninein

2

20

High-throughput

0.584

High

1115607

WWTR1
WW domain-containing transcription regulator protein 1

2

18

Small-scale

0.584

High

211565

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

13

Small-scale

0.578

High

1115557

PALS1
Protein PALS1

1

3

High-throughput

0.575

High

1115542

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

2

High-throughput

0.574

High

600466

ZNF26
Zinc finger protein 26

1

1

High-throughput

0.573

High

940444

TCL1A
T-cell leukemia/lymphoma protein 1A

1

1

High-throughput

0.573

High

980750

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.573

High

1115525

C19L2
CWF19-like protein 2

1

1

High-throughput

0.573

High

1115548

NUTM1
NUT family member 1

1

1

High-throughput

0.573

High

1115560

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

1

High-throughput

0.573

High

1115598

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

10

High-throughput

0.573

High

1115599

TRAF4
TNF receptor-associated factor 4

1

20

High-throughput

0.573

High

1115624

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.573

High

1115594

CC85A
Coiled-coil domain-containing protein 85A

2

9

High-throughput

0.560

High

1115562

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

1

High-throughput

0.555

High

1115613

PKHF2
Pleckstrin homology domain-containing family F member 2

1

12

High-throughput

0.555

High

1115614

UBTD1
Ubiquitin domain-containing protein 1

1

1

High-throughput

0.555

High

983652

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.549

High

1115576

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.549

High

1115587

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.549

High

1094538

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

8

High-throughput

0.541

High

1115600

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

2

High-throughput

0.541

High

1115620

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

17

Small-scale

0.536

High

66609

CC85C
Coiled-coil domain-containing protein 85C

1

9

High-throughput

0.536

High

296885

RASF9
Ras association domain-containing protein 9

1

11

High-throughput

0.536

High

299760

MPDZ
Multiple PDZ domain protein

1

17

High-throughput

0.536

High

347010

BAG2
BAG family molecular chaperone regulator 2

1

7

High-throughput

0.536

High

402923

ANXA1
Annexin A1

1

3

High-throughput

0.536

High

761674

HSP74
Heat shock 70 kDa protein 4

1

18

High-throughput

0.536

High

928178

HAP1
Huntingtin-associated protein 1

1

7

High-throughput

0.536

High

930881

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.536

High

978921

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.536

High

1067300

EP300
Histone acetyltransferase p300

1

19

Small-scale

0.536

High

1115513

BECN1
Beclin-1

1

2

High-throughput

0.536

High

1115518

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

10

High-throughput

0.536

High

1115519

CC85B
Coiled-coil domain-containing protein 85B

1

9

High-throughput

0.536

High

1115572

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.536

High

1115623

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

6

High-throughput

0.536

High

1115633

AMOL2
Angiomotin-like protein 2

1

20

High-throughput

0.536

High

422074

A4
Amyloid-beta precursor protein

1

6

Small-scale

0.529

High

626219

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.527

High

996140

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

1105122

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

596093

H12
Histone H1.2

1

7

High-throughput

0.515

High

1115515

PLEC
Plectin

1

10

High-throughput

0.515

High

1115591

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

184711

ATX7
Ataxin-7

1

11

High-throughput

0.508

High

995025

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.508

High

1115564

PPHLN
Periphilin-1

1

1

High-throughput

0.508

High

636730

PTN
Pleiotrophin

1

1

High-throughput

0.494

High

1115610

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.489

High

1115634

EMIL1
EMILIN-1

1

6

High-throughput

0.489

High

49318

SHOT1
Shootin-1

1

2

High-throughput

0.481

High

181106

AXIN1
Axin-1

1

8

High-throughput

0.481

High

210275

PHF1
PHD finger protein 1

1

3

High-throughput

0.481

High

225582

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

3

High-throughput

0.481

High

269194

HSF2B
Heat shock factor 2-binding protein

1

4

High-throughput

0.481

High

297979

SPF27
Pre-mRNA-splicing factor SPF27

1

2

High-throughput

0.481

High

347690

BAG3
BAG family molecular chaperone regulator 3

1

8

High-throughput

0.481

High

570419

GFAP
Glial fibrillary acidic protein

1

15

High-throughput

0.481

High

634432

LMNB1
Lamin-B1

1

15

High-throughput

0.481

High

704529

RXRB
Retinoic acid receptor RXR-beta

1

20

High-throughput

0.481

High

1040486

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

13

High-throughput

0.481

High

1086494

TROAP
Tastin

1

1

High-throughput

0.481

High

1098544

GPS2
G protein pathway suppressor 2

1

1

High-throughput

0.481

High

1115512

ELOA1
Elongin-A

1

17

High-throughput

0.481

High

1115524

CCD57
Coiled-coil domain-containing protein 57

1

10

High-throughput

0.481

High

1115528

CEP55
Centrosomal protein of 55 kDa

1

4

High-throughput

0.481

High

1115533

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.481

High

1115543

ZN438
Zinc finger protein 438

1

3

High-throughput

0.481

High

1115547

ZN575
Zinc finger protein 575

1

3

High-throughput

0.481

High

1115551

RASL3
RAS protein activator like-3

1

7

High-throughput

0.481

High

1115554

CCD13
Coiled-coil domain-containing protein 13

1

9

High-throughput

0.481

High

1115556

MTURN
Maturin

1

1

High-throughput

0.481

High

1115570

PIBF1
Progesterone-induced-blocking factor 1

1

5

High-throughput

0.481

High

1115573

CBP
CREB-binding protein

1

15

Small-scale

0.481

High

1115574

GOGA1
Golgin subfamily A member 1

1

10

High-throughput

0.481

High

1115577

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.481

High

1115583

GCC1
GRIP and coiled-coil domain-containing protein 1

1

11

High-throughput

0.481

High

1115586

CEP95
Centrosomal protein of 95 kDa

1

1

High-throughput

0.481

High

1115589

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

6

High-throughput

0.481

High

1115597

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.481

High

1115601

SCNM1
Sodium channel modifier 1

1

4

High-throughput

0.481

High

1115604

TSG10
Testis-specific gene 10 protein

1

18

High-throughput

0.481

High

1115605

SETD5
Histone-lysine N-methyltransferase SETD5

1

9

High-throughput

0.481

High

1115612

ZN552
Zinc finger protein 552

1

5

High-throughput

0.481

High

1115622

CING
Cingulin

1

6

High-throughput

0.481

High

245319

CE104
Centrosomal protein of 104 kDa

1

1

High-throughput

0.479

High

324129

CE152
Centrosomal protein of 152 kDa

1

7

High-throughput

0.479

High

371972

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

466665

GLI1
Zinc finger protein GLI1

1

6

Small-scale

0.479

High

475574

K1C19
Keratin, type I cytoskeletal 19

1

10

High-throughput

0.479

High

588648

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

695407

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

730570

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764328

CTNA1
Catenin alpha-1

1

8

High-throughput

0.479

High

833263

PERI
Peripherin

1

14

High-throughput

0.479

High

896524

VASP
Vasodilator-stimulated phosphoprotein

1

10

High-throughput

0.479

High

936320

AFAD
Afadin

1

20

High-throughput

0.479

High

952808

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.479

High

986409

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

1087102

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1096678

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

1109704

HDAC1
Histone deacetylase 1

1

9

High-throughput

0.479

High

1110834

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

5

Small-scale

0.479

High

1115521

OCLN
Occludin

1

3

High-throughput

0.479

High

1115530

ODFP2
Outer dense fiber protein 2

1

8

High-throughput

0.479

High

1115532

CE162
Centrosomal protein of 162 kDa

1

16

High-throughput

0.479

High

1115534

CP135
Centrosomal protein of 135 kDa

1

12

High-throughput

0.479

High

1115538

SYNE3
Nesprin-3

1

17

High-throughput

0.479

High

1115545

CNTRL
Centriolin

1

9

High-throughput

0.479

High

1115546

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1115553

CEP97
Centrosomal protein of 97 kDa

1

8

High-throughput

0.479

High

1115555

CNTRB
Centrobin

1

10

High-throughput

0.479

High

1115566

FBF1
Fas-binding factor 1

1

17

High-throughput

0.479

High

1115581

PF21A
PHD finger protein 21A

1

14

High-throughput

0.479

High

1115593

SCLT1
Sodium channel and clathrin linker 1

1

14

High-throughput

0.479

High

1115596

CEP89
Centrosomal protein of 89 kDa

1

12

High-throughput

0.479

High

1115606

CEP44
Centrosomal protein of 44 kDa

1

2

High-throughput

0.479

High

1115608

ATG5
Autophagy protein 5

1

2

Small-scale

0.479

High

1115615

CPAP
Centrosomal P4.1-associated protein

1

11

High-throughput

0.479

High

1115617

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.479

High

1115626

XPO7
Exportin-7

1

12

High-throughput

0.479

High

1115628

RCOR1
REST corepressor 1

1

10

High-throughput

0.479

High

289995

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

991841

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

1115537

Q6NSK7
RIN3 protein

1

4

High-throughput

0.457

High

160502

IRS4
Insulin receptor substrate 4

1

3

Small-scale

0.445

High

890318

NU153
Nuclear pore complex protein Nup153

1

20

Small-scale

0.445

High

965546

NTF2
Nuclear transport factor 2

1

3

Small-scale

0.445

High

1115541

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.445

High

946238

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

2

High-throughput

0.439

High

1041989

LMNB2
Lamin-B2

1

12

High-throughput

0.439

High

1115531

EFHC1
EF-hand domain-containing protein 1

1

2

High-throughput

0.439

High

1115539

INSY2
Inhibitory synaptic factor 2A

1

1

High-throughput

0.439

High

1115579

RGMA
Repulsive guidance molecule A

1

2

High-throughput

0.439

High

1115595

PRAM
PML-RARA-regulated adapter molecule 1

1

12

High-throughput

0.439

High

1115522

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

2

High-throughput

0.437

High

1115536

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

High-throughput

0.437

High

1115540

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.437

High

1115582

ENTR1
Endosome-associated-trafficking regulator 1

1

3

High-throughput

0.437

High

1115523

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1115602

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.282

High

834118

IPP2
Protein phosphatase inhibitor 2

1

0

High-throughput

0.279

Low

1115571

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025