HitPredict

Interactor 1: ACTB (P60710)
Actin, cytoplasmic 1 (Beta-actin) (EC 3.6.4.-) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: PROF2 (Q9JJV2)
Profilin-2 (Profilin II)
Gene: Pfn2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	11034907, 9463375, 17541406
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Actin~Profilin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0016887 - ATP hydrolysis activity GO:0098685 - Schaffer collateral - CA1 synapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 375 Mm			1 140
+	Hs
		714971 ACTBL_HUMAN (2-375): 0: 735: 91.71		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		891642 ACTBL_HUMAN (2-375): 0: 735: 91.71		PROF3_HUMAN (1-139): 1.5e-66: 199: 41.01
+	Bt
		361199 ACTB_BOVIN (1-375): 0: 603: 100.00		PROF1_BOVIN (1-140): 2.69e-76: 224: 62.14
+	Hs
		714946 ACTB_HUMAN (1-375): 0: 603: 100.00		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		430115 ACTB_HUMAN (1-375): 0: 603: 100.00		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Hs
		714953 ACTG_HUMAN (1-375): 0: 601: 98.93		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Mm
		892155 ACTB_MOUSE (1-375): 0: 603: 100.00		PROF1_MOUSE (1-140): 2.28e-75: 222: 62.86
+	Hs
		430128 ACTG_HUMAN (1-375): 0: 601: 98.93		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Bt
		361200 ACTS_BOVIN (2-375): 0: 592: 93.58		PROF1_BOVIN (1-140): 2.69e-76: 224: 62.14
+	Hs
		714954 ACTC_HUMAN (2-375): 0: 592: 94.12		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		430130 ACTC_HUMAN (2-375): 0: 592: 94.12		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Hs
		714951 ACTA_HUMAN (2-375): 0: 591: 94.12		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		430125 ACTA_HUMAN (2-375): 0: 591: 94.12		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Hs
		891639 ACTB_HUMAN (1-375): 0: 603: 100.00		PROF3_HUMAN (1-139): 1.5e-66: 199: 41.01
+	Hs
		891641 ACTC_HUMAN (2-375): 0: 592: 94.12		PROF3_HUMAN (1-139): 1.5e-66: 199: 41.01
+	Hs
		891640 ACTA_HUMAN (2-375): 0: 591: 94.12		PROF3_HUMAN (1-139): 1.5e-66: 199: 41.01