HitPredict

Interactor 1: SEM1 (P60896)
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)
Gene: SEM1

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	28396413, 24811749, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 70 Hs			1 1083
+	Hs
		893570 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		UBE3B_HUMAN (21-1083): 0: 877: 26.51
+	Hs
		893539 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		893571 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60