Protein: GBG5
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene: GBG5, GNG5
Organism: Homo sapiens
Interactions: 56
UniProt ID: P63218

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

983448

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

11

20

Small-scale

0.755

High

984065

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

6

20

Small-scale

0.731

High

597354

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

4

20

Small-scale

0.703

High

475944

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

20

High-throughput

0.691

High

992453

GBB4
Guanine nucleotide-binding protein subunit beta-4

4

20

Small-scale

0.690

High

418647

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

20

High-throughput

0.667

High

989827

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

3

20

High-throughput

0.667

High

989713

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

3

20

High-throughput

0.656

High

163630

GNB5
Guanine nucleotide-binding protein subunit beta-5

2

20

Small-scale

0.614

High

683432

IKBA
NF-kappa-B inhibitor alpha

2

1

High-throughput

0.611

High

992447

S2541
Mitochondrial carrier protein SCaMC-3L

3

2

High-throughput

0.609

High

992444

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

2

0

High-throughput

0.602

High

992442

K1H1
Keratin, type I cuticular Ha1

1

8

High-throughput

0.573

High

992456

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

1

High-throughput

0.573

High

992461

AMOL2
Angiomotin-like protein 2

1

3

High-throughput

0.573

High

948770

CD81
CD81 antigen

2

4

Small-scale

0.571

High

992450

UIF
UAP56-interacting factor

2

2

High-throughput

0.558

High

992452

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

1

High-throughput

0.558

High

332962

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

4

High-throughput

0.536

High

529580

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.536

High

638180

S1PR1
Sphingosine 1-phosphate receptor 1

1

3

High-throughput

0.536

High

716020

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

20

High-throughput

0.536

High

893480

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

High-throughput

0.536

High

992438

PHLP
Phosducin-like protein

1

11

High-throughput

0.536

High

992440

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

20

High-throughput

0.536

High

992454

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.536

High

992455

VAPA
Vesicle-associated membrane protein-associated protein A

1

4

High-throughput

0.536

High

992436

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.523

High

992443

K1C40
Keratin, type I cytoskeletal 40

1

8

High-throughput

0.523

High

698568

CALX
Calnexin

1

0

High-throughput

0.513

High

888847

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

925515

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.513

High

951089

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

976193

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.513

High

992439

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.513

High

992449

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.513

High

992462

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

0

High-throughput

0.513

High

992463

IR3IP
Immediate early response 3-interacting protein 1

1

0

High-throughput

0.513

High

337642

GNAS3
Neuroendocrine secretory protein 55

2

8

High-throughput

0.504

High

992445

C1QL4
Complement C1q-like protein 4

1

2

High-throughput

0.489

High

375382

RASK
GTPase KRas

1

1

High-throughput

0.479

High

942543

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

959125

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

247813

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

992458

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

992459

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

1

High-throughput

0.437

High

992441

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.426

High

992460

PPR3C
Protein phosphatase 1 regulatory subunit 3C

2

0

High-throughput

0.318

High

992437

TRAF1
TNF receptor-associated factor 1

1

0

High-throughput

0.299

High

992451

MDFI
MyoD family inhibitor

1

0

High-throughput

0.299

High

928615

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.279

Low

992446

CARME
Carnosine N-methyltransferase

1

0

High-throughput

0.279

Low

992448

SERP2
Stress-associated endoplasmic reticulum protein 2

1

0

High-throughput

0.279

Low

992457

GULP1
PTB domain-containing engulfment adapter protein 1

1

0

High-throughput

0.279

Low

275004

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

612967

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025