HitPredict

Interactor 1: RAB14 (P61106)
Ras-related protein Rab-14 (EC 3.6.5.2)
Gene: RAB14

Interactor 2: RUFY1 (Q96T51)
RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)
Gene: RUFY1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.828

Property	Details
Experiments	36282215, 20534812
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RUN~Ras
Common GO terms	GO:0005829 - cytosol GO:0031901 - early endosome membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 708
+	Hs
		895236 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Hs
		591988 RAB4A_HUMAN (8-215): 1.05e-87: 259: 60.77		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Hs
		914301 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Dm
		1197049 Q86BK8_DROME (1-215): 2.42e-85: 254: 81.40		Q9W2M0_DROME (319-704): 5.75e-46: 175: 19.74
+	Hs
		592071 RAB4A_HUMAN (8-215): 1.05e-87: 259: 60.77		FYV1_HUMAN (545-708): 1.05e-38: 156: 25.56
+	Hs
		895143 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		RUFY3_HUMAN (109-527): 2.56e-32: 132: 56.33
+	Hs
		895123 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		895066 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		ROCK1_HUMAN (102-638): 4.76e-13: 74.9: 12.96
+	Hs
		254463 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		ROCK2_HUMAN (348-660): 2.44e-10: 66.1: 12.81
+	Hs
		895105 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95
+	Hs
		914124 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		591838 RAB4A_HUMAN (8-215): 1.05e-87: 259: 60.77		ROCK1_HUMAN (102-638): 4.76e-13: 74.9: 12.96
+	Hs
		591852 RAB4A_HUMAN (8-215): 1.05e-87: 259: 60.77		EEA1_HUMAN (326-667): 1.35e-11: 70.4: 11.92
+	Hs
		591955 RAB4A_HUMAN (8-215): 1.05e-87: 259: 60.77		RUFY2_HUMAN (99-467): 1.2e-11: 70: 10.84
+	Hs
		914405 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		MTMR4_HUMAN (580-696): 4.56e-12: 71.6: 29.93
+	Hs
		313502 RAB4A_HUMAN (8-215): 1.05e-87: 259: 60.77		ZFYV9_HUMAN (639-700): 4.53e-10: 65.5: 41.27
+	Hs
		914203 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		WDFY3_HUMAN (639-696): 1.25e-10: 67.4: 43.33
+	Hs
		254466 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		ROCK2_HUMAN (348-660): 2.44e-10: 66.1: 12.81
+	Hs
		313523 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		ZFYV9_HUMAN (639-700): 4.53e-10: 65.5: 41.27
+	Hs
		914103 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95