HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHPN1 (Q8TCX5)
Rhophilin-1 (GTP-Rho-binding protein 1)
Gene: RHPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	14749388, 34591642
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HR1~Ras, PDZ~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 670
+	Hs
		900659 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHPN2_HUMAN (3-596): 0: 630: 44.82
+	Hs
		915806 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		RHPN2_HUMAN (3-596): 0: 630: 44.82
+	Hs
		436356 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		BROX_HUMAN (113-494): 6.56e-67: 227: 16.27
+	Hs
		915745 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		BROX_HUMAN (113-494): 6.56e-67: 227: 16.27
+	Hs
		158270 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LIN7A_HUMAN (457-615): 6.95e-35: 134: 20.00
+	Hs
		951362 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GOPC_HUMAN (289-623): 4.04e-32: 131: 15.88
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (512-598): 6.51e-24: 109: 32.63
+	Hs
		167081 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARHGB_HUMAN (512-598): 6.51e-24: 109: 32.63
+	Hs
		167063 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ARHGB_HUMAN (512-598): 6.51e-24: 109: 32.63
+	Hs
		167077 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ARHGB_HUMAN (512-598): 6.51e-24: 109: 32.63
+	Hs
		167079 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		ARHGB_HUMAN (512-598): 6.51e-24: 109: 32.63
+	Mm
		925797 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		DLG4_MOUSE (460-595): 1.7e-18: 91.9: 19.86
+	Mm
		1111996 Q3TLP8_MOUSE (1-193): 3.88e-75: 226: 51.64		DLG4_MOUSE (460-595): 1.7e-18: 91.9: 19.86
+	Hs
		900762 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DLG3_HUMAN (438-592): 2.5e-14: 78.8: 17.58
+	Hs
		951207 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		DLG3_HUMAN (438-592): 2.5e-14: 78.8: 17.58
+	Hs
		900710 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31
+	Hs
		892525 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		DLG3_HUMAN (438-592): 2.5e-14: 78.8: 17.58
+	Hs
		915880 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		DLG3_HUMAN (438-592): 2.5e-14: 78.8: 17.58
+	Hs
		915848 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31