HitPredict

Interactor 1: SMCA2 (P51531)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha)
Gene: SMARCA2

Interactor 2: SMCA4 (P51532)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)
Gene: SMARCA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.906

The method score is based on:

Property Details
Experiments 18042045, 31753913, 24981860, 35235311, 14559996
Identification Methods affinity chromatography technology, cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Bromodomain~Bromodomain, Helicase_C~Helicase_C, Helicase_C~SnAC, Helicase_C~SNF2-rel_dom, HSA~SNF2-rel_dom, SNF2-rel_dom~SnAC, SNF2-rel_dom~SNF2-rel_dom
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
and 31 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1590
Hs

1 1647
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025